S
Stijn Mouton
Researcher at University Medical Center Groningen
Publications - 25
Citations - 423
Stijn Mouton is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Macrostomum lignano & Planarian. The author has an hindex of 12, co-authored 23 publications receiving 332 citations. Previous affiliations of Stijn Mouton include Utrecht University & University Medical Center Utrecht.
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Journal ArticleDOI
Guanine quadruplex structures localize to heterochromatin
Roland F. Hoffmann,Yuri M. Moshkin,Stijn Mouton,Nicola A. Grzeschik,Ruby D. Kalicharan,Jeroen Kuipers,Anouk H G Wolters,Kazuki Nishida,Aleksander V. Romashchenko,Jan Postberg,Hans J. Lipps,Eugene Berezikov,Ody C. M. Sibon,Ben N G Giepmans,Peter M. Lansdorp,Peter M. Lansdorp +15 more
TL;DR: The unexpected presence of G4 structures in heterochromatin and the difference in G4 staining between somatic cells and stem cells with germline DNA in ciliates, flatworms, flies and mammals point to a conserved role for G 4 structures in nuclear organization and cellular differentiation.
Journal ArticleDOI
Efficient transgenesis and annotated genome sequence of the regenerative flatworm model Macrostomum lignano
Jakub Wudarski,Daniil Simanov,Daniil Simanov,Kirill Ustyantsev,Katrien De Mulder,Katrien De Mulder,Margriet Grelling,Magda Grudniewska,Frank W. Beltman,Lisa Glazenburg,Turan Demircan,Turan Demircan,Turan Demircan,Julia Wunderer,Weihong Qi,Dita B. Vizoso,Philipp M. Weissert,Daniel Olivieri,Stijn Mouton,Victor Guryev,A. Aziz Aboobaker,Lukas Schärer,Peter Ladurner,Eugene Berezikov +23 more
TL;DR: It is demonstrated that microinjection of DNA constructs into fertilized one-cell stage eggs, followed by a low dose of irradiation, frequently results in random integration of the transgene in the genome and its stable transmission through the germline.
Journal ArticleDOI
Transcriptional signatures of somatic neoblasts and germline cells in Macrostomum lignano.
Magda Grudniewska,Stijn Mouton,Stijn Mouton,Daniil Simanov,Daniil Simanov,Frank W. Beltman,Margriet Grelling,Katrien de Mulder,Wibowo Arindrarto,Philipp M. Weissert,Stefan van der Elst,Eugene Berezikov,Eugene Berezikov +12 more
TL;DR: A de novo transcriptome assembly is generated and the first comprehensive characterization of gene expression in the proliferating cells of M. lignano is performed, confirming their crucial role for the functionality of somatic neoblasts during homeostasis and regeneration.
Journal ArticleDOI
The free-living flatworm Macrostomum lignano: A new model organism for ageing research
Stijn Mouton,Maxime Willems,Bart P. Braeckman,Bernhard Egger,Peter Ladurner,Lukas Schärer,Gaetan Borgonie +6 more
TL;DR: This work presents a new model organism which can study the causal relation between stem cells, ageing and rejuvenation where other model systems fail, and describes the flatworm M. lignano, which possesses a dynamic population of likely totipotent somatic stem cells known as neoblasts.
Journal ArticleDOI
The free-living flatworm Macrostomum lignano.
Jakub Wudarski,Bernhard Egger,Steven A. Ramm,Lukas Schärer,Peter Ladurner,Kira S. Zadesenets,Nikolay B. Rubtsov,Stijn Mouton,Eugene Berezikov +8 more
TL;DR: A free-living flatworm that is emerging as an attractive experimental animal for research on a broad range of biological questions, one feature setting it apart from other flatworms is the successful establishment of transgenesis methods, facilitated by a steady supply of eggs in the form of single-cell zygotes that can be readily manipulated.