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Suet Yi Leung
Researcher at University of Hong Kong
Publications - 252
Citations - 34944
Suet Yi Leung is an academic researcher from University of Hong Kong. The author has contributed to research in topics: Cancer & Gene. The author has an hindex of 68, co-authored 239 publications receiving 32462 citations. Previous affiliations of Suet Yi Leung include University of Missouri & Queen Mary University of London.
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Journal ArticleDOI
Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer.
Tsun Leung Chan,Siu Tsan Yuen,Siu Tsan Yuen,Chi Kwan Kong,Yee Wai Chan,Annie S Y Chan,Wai Fu Ng,Wai Yin Tsui,Michelle W S Lo,Wing Yip Tam,Vivian S. W. Li,Suet Yi Leung +11 more
TL;DR: A family with inheritance, in three successive generations, of germline allele-specific and mosaic hypermethylation of the MSH2 gene, without evidence of DNA mismatch repair gene mutation is reported.
Journal ArticleDOI
Variation in Gene Expression Patterns in Human Gastric Cancers
Xin Chen,Suet Yi Leung,Siu Tsan Yuen,Kent-Man Chu,Jiafu Ji,Rui Li,Annie S Y Chan,Simon Law,Olga G. Troyanskaya,John Wong,Samuel So,David Botstein,Patrick O. Brown +12 more
TL;DR: A diversity of gene expression patterns in gastric cancer is found, reflecting variation in intrinsic properties of tumor and normal cells and variation in the cellular composition of these complex tissues.
Journal ArticleDOI
Risk of colorectal and endometrial cancers in EPCAM deletion-positive Lynch syndrome: a cohort study
Marlies Kempers,Roland P. Kuiper,Charlotte W. Ockeloen,Pierre O. Chappuis,Pierre Hutter,Nils Rahner,Hans K. Schackert,Verena Steinke,Elke Holinski-Feder,Monika Morak,Matthias Kloor,Reinhard Büttner,Eugène T P Verwiel,J. Han van Krieken,Iris D. Nagtegaal,Monique Goossens,Rachel S. van der Post,Renee C. Niessen,Rolf H. Sijmons,Irma Kluijt,Frans B. L. Hogervorst,Edward M Leter,Johan J.P. Gille,Cora M. Aalfs,Egbert J.W. Redeker,Frederik J. Hes,Carli M. J. Tops,Bernadette P M van Nesselrooij,Marielle E. van Gijn,Encarna B. Gomez Garcia,Diana Eccles,David J. Bunyan,Sapna Syngal,Elena M. Stoffel,Julie O. Culver,Melanie R. Palomares,Tracy Graham,Lea Velsher,János Papp,Edith Olah,Tsun Leung Chan,Suet Yi Leung,Ad Geurts van Kessel,Lambertus A. Kiemeney,Nicoline Hoogerbrugge,Marjolijn J L Ligtenberg +45 more
TL;DR: The results underscore the effect of mosaic MSH2 deficiency, leading to variable cancer risks, and could form the basis of an optimised protocol for the recognition and targeted prevention of cancer in EPCAM deletion carriers.
Journal ArticleDOI
Recurrent KRAS Codon 146 Mutations in Human Colorectal Cancer
Sarah Edkins,Sarah O’Meara,Adrian Parker,Claire Stevens,Marcelo Reis,Siân Jones,Christopher Greenman,Helen Davies,Gillian L. Dalgliesh,Simon A. Forbes,Christopher I. Hunter,Raffaella Smith,Philip J. Stephens,Peter Goldstraw,Andrew G. Nicholson,Tsun Leung Chan,Victor E. Velculescu,Siu Tsan Yuen,Suet Yi Leung,Michael R. Stratton,Michael R. Stratton,P. Andrew Futreal +21 more
TL;DR: Recurrent somatic missense mutations at alanine 146, a highly conserved residue in the guanine nucleotide binding domain, are identified, suggesting that the contribution of codon 146 mutations is not entirely restricted to colorectal cancers or to KRAS.
Journal ArticleDOI
N‐Myc downstream‐regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation
Yanchun Deng,Libo Yao,Ling Chau,Samuel Sai Ming Ng,Ying Peng,Xinping Liu,WS Au,Jicun Wang,Fuyang Li,Shaoping Ji,Hua Han,Xiaoyan Nie,Qing Li,Hsiang-Fu Kung,Suet Yi Leung,Marie Chia Mi Lin +15 more
TL;DR: These findings provide the first evidence to suggest that the human N‐Myc downstream‐regulated gene 2 (hNDRG2), located at chromosome 14q11.2, may play a role in glioblastoma carcinogenesis.