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Suet Yi Leung
Researcher at University of Hong Kong
Publications - 252
Citations - 34944
Suet Yi Leung is an academic researcher from University of Hong Kong. The author has contributed to research in topics: Cancer & Gene. The author has an hindex of 68, co-authored 239 publications receiving 32462 citations. Previous affiliations of Suet Yi Leung include University of Missouri & Queen Mary University of London.
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Journal ArticleDOI
Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors.
Cynthia Kosinski,Vivian S. W. Li,Annie S Y Chan,Ji Zhang,Coral Ho,Wai Yin Tsui,Tsun Leung Chan,Randy C. Mifflin,Don W. Powell,Siu Tsan Yuen,Suet Yi Leung,Xin Chen +11 more
TL;DR: This study suggests that BMP antagonists are candidate signaling components that make up the intestinal epithelial stem cell niche, and applies gene expression analysis of normal human colon tops and basal crypts to provide a comprehensive picture of human colonic epithelial cell differentiation.
Journal ArticleDOI
Somatic Mutations of the Protein Kinase Gene Family in Human Lung Cancer
Helen Davies,Christopher I. Hunter,Raffaella Smith,Philip J. Stephens,Christopher Greenman,Graham R. Bignell,Jon W. Teague,Adam Butler,Sarah Edkins,Claire Stevens,Adrian Parker,Sarah O’Meara,Tim Avis,Syd Barthorpe,Lisa Brackenbury,Gemma Buck,Jody Clements,Jennifer Cole,Ed Dicks,Ken Edwards,Simon A. Forbes,Matthew Gorton,Kristian Gray,Kelly Halliday,Rachel Harrison,Katy Hills,Jonathon Hinton,David Jones,Vivienne Kosmidou,Ross Laman,Richard Lugg,Andrew Menzies,Janet Perry,Robert Petty,Keiran Raine,Rebecca Shepherd,Alexandra Small,Helen Solomon,Yvonne Stephens,Calli Tofts,Jennifer Varian,Anthony Webb,Sofie West,Sara Widaa,Andrew D. Yates,Francis Brasseur,Colin Cooper,Adrienne M. Flanagan,Anthony R. Green,Maggie Knowles,Suet Yi Leung,Leendert H. J. Looijenga,Bruce Malkowicz,Marco A. Pierotti,Bin Tean Teh,Siu Tsan Yuen,Sunil R. Lakhani,Douglas F. Easton,Barbara L. Weber,Peter Goldstraw,Andrew G. Nicholson,Richard Wooster,Richard Wooster,Michael R. Stratton,P. Andrew Futreal +64 more
TL;DR: The results suggest that several mutated protein kinases may be contributing to lung cancer development, but that mutations in each one are infrequent.
Journal Article
Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia.
Siu Tsan Yuen,Helen Davies,Tsun Leung Chan,Judy W. C. Ho,Graham R. Bignell,Charles Cox,Philip J. Stephens,Sarah Edkins,Wendy Wai Yin Tsui,Annie S. Chan,P. Andrew Futreal,Michael R. Stratton,Richard Wooster,Suet Yi Leung +13 more
TL;DR: The data suggest that BRAF mutations are, to some extent, biologically similar to RAS mutations in colorectal cancer because both occur at approximately the same stage of the adenoma-carcinoma sequence, both are associated with villous morphology, and both are less common in adenomas from FAP cases.
Journal ArticleDOI
Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database
Bryony A. Thompson,Bryony A. Thompson,Amanda B. Spurdle,John-Paul Plazzer,Marc S. Greenblatt,Kiwamu Akagi,Fahd Al-Mulla,Bharati Bapat,Inge Bernstein,Gabriel Capellá,Johan T. den Dunnen,Desirée du Sart,Aurelie Fabre,Michael Farrell,Susan M. Farrington,Ian M. Frayling,Thierry Frebourg,David E. Goldgar,David E. Goldgar,Christopher D. Heinen,Elke Holinski-Feder,Maija R.J. Kohonen-Corish,Maija R.J. Kohonen-Corish,Maija R.J. Kohonen-Corish,Kristina Lagerstedt Robinson,Suet Yi Leung,Alexandra Martins,Pål Møller,Monika Morak,Minna Nyström,Päivi Peltomäki,Marta Pineda,Ming Qi,Ming Qi,Rajkumar Ramesar,Lene Juel Rasmussen,Brigitte Royer-Pokora,Rodney J. Scott,Rodney J. Scott,Rolf H. Sijmons,Sean V. Tavtigian,Carli M. J. Tops,Thomas P. Weber,Juul T. Wijnen,Michael O. Woods,Finlay A. Macrae,Maurizio Genuardi +46 more
TL;DR: This large-scale endeavor will facilitate the consistent management of families suspected to have Lynch syndrome and demonstrates the value of multidisciplinary collaboration in the curation and classification of variants in public locus-specific databases.
Journal ArticleDOI
A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening.
Helen H.N. Yan,Hoi Cheong Siu,Simon Law,Siu Lun Ho,Sarah S K Yue,Wai Yin Tsui,D Chan,April S. Chan,Stephanie Ma,Ka-On Lam,Sina Bartfeld,Alice H Y Man,Bernard C H Lee,Annie S Y Chan,Jason W. H. Wong,Priscilla S.W. Cheng,Anthony K W Chan,Jiangwen Zhang,Jue Shi,Xiaodan Fan,Dora Lai-Wan Kwong,Tak W. Mak,Siu Tsan Yuen,Siu Tsan Yuen,Hans Clevers,Suet Yi Leung +25 more
TL;DR: A primary gastric cancer organoid biobank that comprises normal, dysplastic, cancer, and lymph node metastases from 34 patients, including detailed whole-exome and transcriptome analysis, provides a useful resource for studying both cancer cell biology and precision cancer therapy.