S
Suk Yun Kang
Researcher at Seoul National University
Publications - 34
Citations - 784
Suk Yun Kang is an academic researcher from Seoul National University. The author has contributed to research in topics: Neuropathic pain & Nociception. The author has an hindex of 18, co-authored 30 publications receiving 674 citations.
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Journal ArticleDOI
Intrathecal injection of carbenoxolone, a gap junction decoupler, attenuates the induction of below-level neuropathic pain after spinal cord injury in rats.
Dae Hyun Roh,Seo Yeon Yoon,Hyoung Sig Seo,Suk Yun Kang,Ho Jae Han,Alvin J. Beitz,Jang Hern Lee +6 more
TL;DR: Gap junctions play a critical role in the activation of astrocytes distant from the site of SCI and in the subsequent phosphorylation of NMDA receptors in the lumbar spinal cord, which appear to contribute to the induction of bilateral below-level pain in SCI rats.
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Spinal neuronal NOS activation mediates sigma-1 receptor-induced mechanical and thermal hypersensitivity in mice: involvement of PKC-dependent GluN1 phosphorylation
Dae Hyun Roh,Sheu Ran Choi,Seo Yeon Yoon,Suk Yun Kang,Jiyoung Moon,Soon Gu Kwon,Ho Jae Han,Alvin J. Beitz,Jang Hern Lee +8 more
TL;DR: The role of NO is examined in this process, as it plays a critical role in PKC‐mediated calcium signalling and the potentiation of NMDA receptor function.
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An increase in spinal dehydroepiandrosterone sulfate (DHEAS) enhances NMDA-induced pain via phosphorylation of the NR1 subunit in mice: involvement of the sigma-1 receptor.
Seo Yeon Yoon,Dae Hyun Roh,Hyoung Sig Seo,Suk Yun Kang,Jiyoung Moon,Sun Ok Song,Alvin J. Beitz,Jang Hern Lee +7 more
TL;DR: The results of this study suggest that the DHEAS-induced enhancement of NMDA-mediated nociception is dependent on an increase in PKC- and PKA-dependent pNR1.
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Spinal sigma-1 receptors activate NADPH oxidase 2 leading to the induction of pain hypersensitivity in mice and mechanical allodynia in neuropathic rats.
Sheu Ran Choi,Dae Hyun Roh,Seo Yeon Yoon,Suk Yun Kang,Jiyoung Moon,Soon Gu Kwon,Hoon Seong Choi,Ho Jae Han,Alvin J. Beitz,Seog Bae Oh,Jang Hern Lee +10 more
TL;DR: It is demonstrated that spinal Sig-1Rs modulate Nox2 activation and ROS production in the spinal cord, and ultimately contribute to the Sig- 1R-induced pain hypersensitivity and the peripheral nerve injury-induced induction of chronic neuropathic pain.
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Microglial interleukin-1β in the ipsilateral dorsal horn inhibits the development of mirror-image contralateral mechanical allodynia through astrocyte activation in a rat model of inflammatory pain.
Hoon Seong Choi,Dae Hyun Roh,Seo Yeon Yoon,Jiyoung Moon,Sheu Ran Choi,Soon Gu Kwon,Suk Yun Kang,Ho Jae Han,Hyun-Woo Kim,Alvin J. Beitz,Seog Bae Oh,Jang Hern Lee +11 more
TL;DR: Results suggest that spinal IL-1&bgr; derived from activated microglia temporarily suppresses astrocyte activation, which can ultimately prevent the development of contralateral MA under inflammatory conditions, and imply that microglial IL- 1&b gr; plays an important role in regulating the induction of inflammatory MIP.