Journal ArticleDOI
Intrathecal injection of carbenoxolone, a gap junction decoupler, attenuates the induction of below-level neuropathic pain after spinal cord injury in rats.
Dae Hyun Roh,Seo Yeon Yoon,Hyoung Sig Seo,Suk Yun Kang,Ho Jae Han,Alvin J. Beitz,Jang Hern Lee +6 more
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TLDR
Gap junctions play a critical role in the activation of astrocytes distant from the site of SCI and in the subsequent phosphorylation of NMDA receptors in the lumbar spinal cord, which appear to contribute to the induction of bilateral below-level pain in SCI rats.About:
This article is published in Experimental Neurology.The article was published on 2010-07-01. It has received 65 citations till now. The article focuses on the topics: Lumbar Spinal Cord & Spinal cord injury.read more
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Importance of glial activation in neuropathic pain
Joanna Mika,Magdalena Zychowska,Katarzyna Popiolek-Barczyk,Ewelina Rojewska,Barbara Przewlocka +4 more
TL;DR: Since it is known that the opioid-induced glial activation opposes opioid analgesia, some glial inhibitors are proposed as potential useful ko-analgesic agents for opioid treatment of neuropathic pain.
Journal ArticleDOI
Spatial and temporal activation of spinal glial cells: Role of gliopathy in central neuropathic pain following spinal cord injury in rats
TL;DR: Time and regional dependence of glial activation and activation mechanisms in various SCI models in rats are described and demonstrated that dysfunctional glia, a condition called "gliopathy", is a key contributor in the underlying cellular mechanisms contributing to neuropathic pain.
Journal ArticleDOI
Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury
TL;DR: Findings suggest Cx43 is critically linked to the development of central neuropathic pain following acute SCI, and support an important role of astrocytes in theDevelopment of chronic pain.
Journal ArticleDOI
Role of connexins in metastatic breast cancer and melanoma brain colonization.
Konstantin Stoletov,Jan Strnadel,Erin Zardouzian,Masashi Momiyama,Frederick D. Park,Jonathan A. Kelber,Donald P. Pizzo,Robert M. Hoffman,Scott R. VandenBerg,Richard L. Klemke +9 more
TL;DR: Evidence is provided that breast cancer and melanoma cells utilize connexin gap junction proteins (Cx43, Cx26) to initiate brain metastatic lesion formation in association with the vasculature and that connexins might be exploited therapeutically to benefit cancer patients with metastatic disease.
Journal ArticleDOI
Targeting the Microglial Signaling Pathways: New Insights in the Modulation of Neuropathic Pain.
TL;DR: The objective was to identify new molecular targets that may result in the development of powerful tools to control the signaling associated with neuropathic pain.
References
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A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia.
TL;DR: Both the thermal method and the Randall‐Selitto mechanical method detected dose‐related hyperalgesia and its blockade by either morphine or indomethacin, but the Thermal method showed greater bioassay sensitivity and allowed for the measurement of other behavioral parameters in addition to the nociceptive threshold.
Journal Article
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia.
Journal ArticleDOI
A Sensitive and Reliable Locomotor Rating Scale for Open Field Testing in Rats
TL;DR: The data indicate that the BBB scale is a valid and predictive measure of locomotor recovery able to distinguish behavioral outcomes due to different injuries and to predict anatomical alterations at the lesion center.
Journal ArticleDOI
Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation
Micaela Zonta,María Cecilia Angulo,Sara Gobbo,Bernhard Rosengarten,K.-A. Hossmann,Tullio Pozzan,Giorgio Carmignoto +6 more
TL;DR: In vivo blockade of glutamate-mediated [Ca2+]i elevations in astrocytes reduced the blood flow increase in the somatosensory cortex during contralateral forepaw stimulation and showed that neuron-to-astrocyte signaling is a key mechanism in functional hyperemia.
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Functional Hemichannels in Astrocytes: A Novel Mechanism of Glutamate Release
TL;DR: It is shown that astrocytes in vitro express functional hemichannels that can mediate robust efflux of glutamate and aspartate and could influence CNS levels of extracellular glutamate with implications for normal and pathological brain function.
Related Papers (5)
Activated Microglia Contribute to the Maintenance of Chronic Pain after Spinal Cord Injury
Bryan C. Hains,Stephen G. Waxman +1 more