S
Suneet Agarwal
Researcher at Boston Children's Hospital
Publications - 82
Citations - 14519
Suneet Agarwal is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Dyskeratosis congenita & Telomere. The author has an hindex of 30, co-authored 74 publications receiving 13343 citations. Previous affiliations of Suneet Agarwal include Brigham and Women's Hospital & Harvard University.
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Journal ArticleDOI
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Mamta Tahiliani,Kian Peng Koh,Yinghua Shen,William A. Pastor,Hozefa S. Bandukwala,Yevgeny Brudno,Suneet Agarwal,Lakshminarayan M. Iyer,David R. Liu,L. Aravind,Anjana Rao +10 more
TL;DR: It is shown here that TET1, a fusion partner of the MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme that catalyzes conversion of 5mC to 5-hydroxymethylcytosine (hmC) in cultured cells and in vitro.
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Somatic coding mutations in human induced pluripotent stem cells
Athurva Gore,Zhe Li,Ho Lim Fung,Jessica E. Young,Suneet Agarwal,Jessica Antosiewicz-Bourget,Isabel Canto,Alessandra Giorgetti,Mason A. Israel,Evangelos Kiskinis,Je-Hyuk Lee,Yuin-Han Loh,Philip D. Manos,Nuria Montserrat,Athanasia D. Panopoulos,Sergio Ruiz,Melissa L. Wilbert,Junying Yu,Ewen F. Kirkness,Juan Carlos Izpisua Belmonte,Derrick J. Rossi,James A. Thomson,Kevin Eggan,George Q. Daley,Lawrence S.B. Goldstein,Kun Zhang +25 more
TL;DR: It is shown that 22 human induced pluripotent stem (hiPS) cell lines reprogrammed using five different methods each contained an average of five protein-coding point mutations in the regions sampled, and that hiPS cells acquire genetic modifications in addition to epigenetic modifications.
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Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
Myunggon Ko,Yun Huang,Yun Huang,Anna M. Jankowska,Utz Johann Pape,Utz Johann Pape,Mamta Tahiliani,Hozefa S. Bandukwala,Jungeun An,Jungeun An,Edward D. Lamperti,Kian Peng Koh,Rebecca D. Ganetzky,X. Shirley Liu,L. Aravind,Suneet Agarwal,Jaroslaw P. Maciejewski,Anjana Rao,Anjana Rao +18 more
TL;DR: The results demonstrate that Tet2 is important for normal myelopoiesis, and suggest that disruption of TET2 enzymatic activity favours myeloid tumorigenesis, which may prove valuable as a diagnostic and prognostic tool to tailor therapies and assess responses to anticancer drugs.
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Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells
Sabine Loewer,Moran N. Cabili,Moran N. Cabili,Mitchell Guttman,Yuin-Han Loh,Kelly Thomas,Kelly Thomas,In-Hyun Park,Manuel Garber,Matthew Curran,Tamer T. Onder,Suneet Agarwal,Philip D. Manos,Philip D. Manos,Sumon Datta,Sumon Datta,Eric S. Lander,Eric S. Lander,Thorsten M. Schlaeger,Thorsten M. Schlaeger,George Q. Daley,John L. Rinn,John L. Rinn +22 more
TL;DR: In this paper, the authors characterized the transcriptional reorganization of large intergenic non-coding RNAs (lincRNAs) that occurs upon derivation of human iPSCs and identified numerous lincRNA whose expression is linked to pluripotency.
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Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells
William A. Pastor,Utz Johann Pape,Utz Johann Pape,Yun Huang,Hope R. Henderson,Hope R. Henderson,Ryan Lister,Myunggon Ko,Erin M. McLoughlin,Yevgeny Brudno,Sahasransu Mahapatra,Philipp Kapranov,Mamta Tahiliani,Mamta Tahiliani,George Q. Daley,X. Shirley Liu,Joseph R. Ecker,Patrice M. Milos,Suneet Agarwal,Anjana Rao,Anjana Rao +20 more
TL;DR: The results indicate that 5hmC has a probable role in transcriptional regulation, and suggest a model in which5hmC contributes to the ‘poised’ chromatin signature found at developmentally-regulated genes in ES cells.