T
Tak W. Mak
Researcher at Princess Margaret Cancer Centre
Publications - 233
Citations - 48880
Tak W. Mak is an academic researcher from Princess Margaret Cancer Centre. The author has contributed to research in topics: T cell & PTEN. The author has an hindex of 97, co-authored 233 publications receiving 45853 citations. Previous affiliations of Tak W. Mak include University Health Network & University of Hong Kong.
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Journal ArticleDOI
Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4
Paul Waterhouse,Josef M. Penninger,Emma Timms,Andrew Wakeham,Arda Shahinian,Kelvin P. Lee,Craig B. Thompson,Henrik Griesser,Tak W. Mak +8 more
TL;DR: Although CTLA-4-deficient T cells proliferated spontaneously and strongly when stimulated through the T cell receptor, they were sensitive to cell death induced by cross-linking of the Fas receptor and by gamma irradiation, and is vital for the control of lymphocyte homeostasis.
Journal ArticleDOI
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
Vuk Stambolic,Vuk Stambolic,Akira Suzuki,Akira Suzuki,José Luis de la Pompa,José Luis de la Pompa,Christine Mirtsos,Christine Mirtsos,Takehiko Sasaki,Takehiko Sasaki,Jürgen Ruland,Jürgen Ruland,Josef M. Penninger,Josef M. Penninger,David P. Siderovski,David P. Siderovski,Tak W. Mak,Tak W. Mak +17 more
TL;DR: The results show that PTEN may exert its role as a tumor suppressor by negatively regulating the PI3'K/PKB/Akt signaling pathway.
Journal ArticleDOI
Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death
Nicholas Joza,Nicholas Joza,Santos A. Susin,Eric Daugas,William L. Stanford,Sarah K. Cho,Carol Y. J. Li,Takehiko Sasaki,Takehiko Sasaki,Andrew J. Elia,H.-Y. Mary Cheng,H.-Y. Mary Cheng,Luigi Ravagnan,Karine F. Ferri,Naoufal Zamzami,Andrew Wakeham,Razqallah Hakem,Hiroki Yoshida,Young-Yun Kong,Tak W. Mak,Juan Carlos Zúñiga-Pflücker,Guido Kroemer,Josef M. Penninger,Josef M. Penninger +23 more
TL;DR: It is shown that genetic inactivation of AIF renders embryonic stem cells resistant to cell death after serum deprivation, providing genetic evidence for a caspase-independent pathway of programmed cell death that controls early morphogenesis.
Journal ArticleDOI
Differential requirement for caspase 9 in apoptotic pathways in vivo
Razqallah Hakem,Razqallah Hakem,Anne Hakem,Anne Hakem,Gordon S. Duncan,Gordon S. Duncan,Jeffrey T. Henderson,Minna Woo,Minna Woo,Maria S. Soengas,Andrew E. H. Elia,Andrew E. H. Elia,José Luis de la Pompa,José Luis de la Pompa,David Kägi,David Kägi,Wilson Khoo,Wilson Khoo,Julia Potter,Julia Potter,Ritsuko Yoshida,Ritsuko Yoshida,Stephen Kaufman,Scott W. Lowe,Josef M. Penninger,Josef M. Penninger,Tak W. Mak,Tak W. Mak +27 more
TL;DR: Comparison of the requirement for Casp9 and Casp3 in different apoptotic settings indicates the existence of at least four different apoptosis pathways in mammalian cells.
Journal ArticleDOI
Differential T cell costimulatory requirements in CD28-deficient mice
Arda Shahinian,Klaus Pfeffer,Kelvin P. Lee,Thomas M. Kündig,Kenji Kishihara,Andrew Wakeham,Kazuhiro Kawai,Pamela S. Ohashi,Craig B. Thompson,Tak W. Mak +9 more
TL;DR: CD28 is not required for all T cell responses in vivo, suggesting that alternative costimulatory pathways may exist.