T
Tatsuhiko Yuasa
Researcher at Niigata University
Publications - 62
Citations - 1905
Tatsuhiko Yuasa is an academic researcher from Niigata University. The author has contributed to research in topics: Ataxia & Atrophy. The author has an hindex of 22, co-authored 62 publications receiving 1781 citations.
Papers
More filters
Journal ArticleDOI
Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene
Hidetoshi Date,Osamu Onodera,Hajime Tanaka,Kiyoshi Iwabuchi,Kazutoshi Uekawa,Shuichi Igarashi,Ryoko Koike,Tadashi Hiroi,Tatsuhiko Yuasa,Yutaka Awaya,Tetsuo Sakai,Tatsuya Takahashi,Hideki Nagatomo,Yoshiki Sekijima,Izumi Kawachi,Yoshihisa Takiyama,Masatoyo Nishizawa,Nobuyoshi Fukuhara,Kayoko Saito,Sumio Sugano,Shoji Tsuji +20 more
TL;DR: A new gene encoding a member of the histidine triad (HIT) superfamily as the 'causative' gene is identified and called aprataxin; the gene symbol is APTX and it is the first to be linked to a distinct phenotype.
Journal ArticleDOI
Mutations in COQ2 in familial and sporadic multiple-system atrophy the multiple-system atrophy research collaboration
Jun Mitsui,Takashi Matsukawa,Hiroyuki Ishiura,Yoko Fukuda,Yoko Fukuda,Yaeko Ichikawa,Hidetoshi Date,Budrul Ahsan,Yasuo Nakahara,Yoshio Momose,Yuji Takahashi,Atsushi Iwata,Jun Goto,Yorihiro Yamamoto,Makiko Komata,Katsuhiko Shirahige,Kenju Hara,Akiyoshi Kakita,Mitsunori Yamada,Hitoshi Takahashi,Osamu Onodera,Masatoyo Nishizawa,Hiroshi Takashima,Ryozo Kuwano,Hirohisa Watanabe,Mizuki Ito,Gen Sobue,Hiroyuki Soma,Ichiro Yabe,Hidenao Sasaki,Masashi Aoki,Kinya Ishikawa,Hidehiro Mizusawa,Kazuaki Kanai,Takamichi Hattori,Satoshi Kuwabara,Kimihito Arai,Shigeru Koyano,Yoshiyuki Kuroiwa,Kazuko Hasegawa,Tatsuhiko Yuasa,Kenichi Yasui,Kenji Nakashima,Hijiri Ito,Yuishin Izumi,Ryuji Kaji,Takeo Kato,Susumu Kusunoki,Yasushi Osaki,Masahiro Horiuchi,Tomoyoshi Kondo,Shigeo Murayama,Nobutaka Hattori,Mitsutoshi Yamamoto,Miho Murata,Wataru Satake,Tatsushi Toda,Alexandra Durr,Alexis Brice,Alessandro Filla,Thomas Klockgether,Ullrich Wallner,Garth A. Nicholson,Sid Gilman,Clifford W. Shults,Caroline M. Tanner,Walter A. Kukull,Virginia M.-Y. Lee,Eliezer Masliah,Phillip A. Low,Paola Sandroni,John Q. Trojanowski,Laurie J. Ozelius,Tatiana Foroud,Shoji Tsuji +74 more
TL;DR: Functionally impaired variants of COQ2 were associated with an increased risk of multiple-system atrophy in multiplex families and patients with sporadic disease, providing evidence of a role of impaired COQ1 activities in the pathogenesis of this disease.
Journal ArticleDOI
Age at onset influences on wide-ranged clinical features of sporadic amyotrophic lateral sclerosis
Naoki Atsuta,Hirohisa Watanabe,Mizuki Ito,Fumiaki Tanaka,Akiko Tamakoshi,Imaharu Nakano,Masashi Aoki,Shoji Tsuji,Tatsuhiko Yuasa,Hiroki Takano,Hideaki Hayashi,Shigeki Kuzuhara,Gen Sobue +12 more
TL;DR: It is demonstrated that symptomatic features of ALS are strongly influenced by the age at onset by the large scale of samples, suggesting that the initial symptoms determine the major clinical features even in advanced illness.
Journal ArticleDOI
Novel mutations, pseudo‐dominant inheritance, and possible familial affects in patients with autosomal recessive juvenile parkinsonism
Mieko Maruyama,Takeshi Ikeuchi,Masaaki Saito,Atsushi Ishikawa,Tatsuhiko Yuasa,Hajime Tanaka,Shintaro Hayashi,Koichi Wakabayashi,Hitoshi Takahashi,Shoji Tsuji +9 more
TL;DR: Although a wide range of ages at onset was observed, there was no correlation between age at onset and genotype, and multiple mutant alleles were identified in 1 family.
Journal ArticleDOI
Joseph's disease: clinical and pathological studies in a Japanese family.
Tatsuhiko Yuasa,E. Ohama,H Harayama,Mitsunori Yamada,Yasuhiro Kawase,Masatoshi Wakabayashi,Tetsushi Atsumi,Tadashi Miyatake +7 more
TL;DR: Neuropathological findings in one patient revealed degeneration of the dentatorubral and pallidoluysian systems, substantia nigra, pontocerebellar system, Clarke's column and spinocere Bellar tracts, and anterior horn cells, as well as the cranial nuclei in the brainstem in Joseph's disease.