Y
Yasuo Nakahara
Researcher at University of Tokyo
Publications - 24
Citations - 599
Yasuo Nakahara is an academic researcher from University of Tokyo. The author has contributed to research in topics: Fibrodysplasia ossificans progressiva & Rehabilitation. The author has an hindex of 9, co-authored 20 publications receiving 517 citations. Previous affiliations of Yasuo Nakahara include Tokyo Medical and Dental University & Teikyo University.
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Journal ArticleDOI
Mutations in COQ2 in familial and sporadic multiple-system atrophy the multiple-system atrophy research collaboration
Jun Mitsui,Takashi Matsukawa,Hiroyuki Ishiura,Yoko Fukuda,Yoko Fukuda,Yaeko Ichikawa,Hidetoshi Date,Budrul Ahsan,Yasuo Nakahara,Yoshio Momose,Yuji Takahashi,Atsushi Iwata,Jun Goto,Yorihiro Yamamoto,Makiko Komata,Katsuhiko Shirahige,Kenju Hara,Akiyoshi Kakita,Mitsunori Yamada,Hitoshi Takahashi,Osamu Onodera,Masatoyo Nishizawa,Hiroshi Takashima,Ryozo Kuwano,Hirohisa Watanabe,Mizuki Ito,Gen Sobue,Hiroyuki Soma,Ichiro Yabe,Hidenao Sasaki,Masashi Aoki,Kinya Ishikawa,Hidehiro Mizusawa,Kazuaki Kanai,Takamichi Hattori,Satoshi Kuwabara,Kimihito Arai,Shigeru Koyano,Yoshiyuki Kuroiwa,Kazuko Hasegawa,Tatsuhiko Yuasa,Kenichi Yasui,Kenji Nakashima,Hijiri Ito,Yuishin Izumi,Ryuji Kaji,Takeo Kato,Susumu Kusunoki,Yasushi Osaki,Masahiro Horiuchi,Tomoyoshi Kondo,Shigeo Murayama,Nobutaka Hattori,Mitsutoshi Yamamoto,Miho Murata,Wataru Satake,Tatsushi Toda,Alexandra Durr,Alexis Brice,Alessandro Filla,Thomas Klockgether,Ullrich Wallner,Garth A. Nicholson,Sid Gilman,Clifford W. Shults,Caroline M. Tanner,Walter A. Kukull,Virginia M.-Y. Lee,Eliezer Masliah,Phillip A. Low,Paola Sandroni,John Q. Trojanowski,Laurie J. Ozelius,Tatiana Foroud,Shoji Tsuji +74 more
TL;DR: Functionally impaired variants of COQ2 were associated with an increased risk of multiple-system atrophy in multiplex families and patients with sporadic disease, providing evidence of a role of impaired COQ1 activities in the pathogenesis of this disease.
Journal ArticleDOI
Variants associated with Gaucher disease in multiple system atrophy
Jun Mitsui,Takashi Matsukawa,Hidenao Sasaki,Ichiro Yabe,Masaaki Matsushima,Alexandra Durr,Alexis Brice,Hiroshi Takashima,Akio Kikuchi,Masashi Aoki,Hiroyuki Ishiura,Tsutomu Yasuda,Hidetoshi Date,Budrul Ahsan,Atsushi Iwata,Jun Goto,Yaeko Ichikawa,Yasuo Nakahara,Yoshio Momose,Yuji Takahashi,Kenju Hara,Akiyoshi Kakita,Mitsunori Yamada,Hitoshi Takahashi,Osamu Onodera,Masatoyo Nishizawa,Hirohisa Watanabe,Mizuki Ito,Gen Sobue,Kinya Ishikawa,Hidehiro Mizusawa,Kazuaki Kanai,Takamichi Hattori,Satoshi Kuwabara,Kimihito Arai,Shigeru Koyano,Yoshiyuki Kuroiwa,Kazuko Hasegawa,Tatsuhiko Yuasa,Kenichi Yasui,Kenji Nakashima,Hijiri Ito,Yuishin Izumi,Ryuji Kaji,Takeo Kato,Susumu Kusunoki,Yasushi Osaki,Masahiro Horiuchi,Tomoyoshi Kondo,Shigeo Murayama,Nobutaka Hattori,Mitsutoshi Yamamoto,Miho Murata,Wataru Satake,Tatsushi Toda,Alessandro Filla,Thomas Klockgether,Ullrich Wüllner,Garth A. Nicholson,Sid Gilman,Caroline M. Tanner,Walter A. Kukull,Mathew B. Stern,Virginia M.-Y. Lee,John Q. Trojanowski,Eliezer Masliah,Phillip A. Low,Paola Sandroni,Laurie J. Ozelius,Tatiana Foroud,Shoji Tsuji +70 more
TL;DR: In this paper, the role of GBA variants in multiple system atrophy (MSA) was investigated in a large case-control series, and the results indicated that, as in PD and DLB, GBA-causing variants are associated with MSA.
Journal ArticleDOI
Appropriate data cleaning methods for genome-wide association study
Taku Miyagawa,Nao Nishida,Jun Ohashi,Ryosuke Kimura,Ryosuke Kimura,Akihiro Fujimoto,Minae Kawashima,Asako Koike,Tsukasa Sasaki,Hisashi Tanii,Takeshi Otowa,Yoshio Momose,Yasuo Nakahara,Jun Gotoh,Yuji Okazaki,Shoji Tsuji,Katsushi Tokunaga +16 more
TL;DR: The criteria required for the appropriate cleaning of 389 unrelated healthy Japanese samples analyzed using the GeneChip Human Mapping 500K Array Set for GWAS were investigated and it was found that appropriate data cleaning could be achieved using these four parameters.
Journal ArticleDOI
Posterior column ataxia with retinitis pigmentosa in a Japanese family with a novel mutation in FLVCR1
Hiroyuki Ishiura,Yoko Fukuda,Jun Mitsui,Yasuo Nakahara,Budrul Ahsan,Yuji Takahashi,Yaeko Ichikawa,Jun Goto,Tetsuo Sakai,Shoji Tsuji +9 more
TL;DR: It is confirmed that PCARP is caused by mutations in FLVCR1, which cosegregated with the disease and a Japanese consanguineous family with PCARP was described.
Journal ArticleDOI
SNP HiTLink: a high-throughput linkage analysis system employing dense SNP data
Yoko Fukuda,Yasuo Nakahara,Hidetoshi Date,Yuji Takahashi,Jun Goto,Akinori Miyashita,Ryozo Kuwano,Hiroki Adachi,Eiji Nakamura,Shoji Tsuji +9 more
TL;DR: In this article, microarray-based single nucleotide polymorphism (SNP) data are becoming more widely used as markers for linkage analysis in the identification of loci for disease-associated genes.