ALL-1 Is a Histone Methyltransferase that Assembles a Supercomplex of Proteins Involved in Transcriptional Regulation
Tatsuya Nakamura,Toshiki Mori,Shinichiro Tada,Wladyslaw A. Krajewski,Tanya Rozovskaia,Richard Wassell,Garrett C. Dubois,Alexander Mazo,Carlo M. Croce,Eli Canaani +9 more
TLDR
Chromatin immunoprecipitations show that ALL-1 and other complex components examined are bound at the promoter of an active ALL- 1-dependent Hox a9 gene, and histones H3 and H4 are acetylated at this promoter.About:
This article is published in Molecular Cell.The article was published on 2002-11-01 and is currently open access. It has received 769 citations till now. The article focuses on the topics: Histone methylation & Histone methyltransferase complex.read more
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The history of cancer epigenetics.
TL;DR: This timeline traces the field from its conception to the present day and addresses the genetic basis of epigenetic changes — an emerging area that promises to unite cancer genetics and epigenetics, and might serve as a model for understanding the epigenetic basis of human disease more generally.
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Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
Mario F. Fraga,Esteban Ballestar,Ana Villar-Garea,Manuel Boix-Chornet,Jesús Espada,Gunnar Schotta,Tiziana Bonaldi,Claire E. Haydon,Santiago Ropero,Kevin Petrie,N. Gopalakrishna Iyer,Alberto Pérez-Rosado,Enrique Calvo,Juan Antonio López,Amparo Cano,María José Calasanz,Dolors Colomer,Miguel A. Piris,Natalie G. Ahn,Natalie G. Ahn,Axel Imhof,Carlos Caldas,Thomas Jenuwein,Manel Esteller +23 more
TL;DR: It is found that cancer cells had a loss of monoacetylated and trimethylated forms of histone H4 early and accumulated during the tumorigenic process, which is a common hallmark of human tumor cells.
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The molecular hallmarks of epigenetic control
C. David Allis,Thomas Jenuwein +1 more
TL;DR: A personal perspective on the development of epigenetics, from its historical origins to what is defined as 'the modern era of epigenetic research', is provided.
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Histone methylation: a dynamic mark in health, disease and inheritance
Eric L. Greer,Yang Shi +1 more
TL;DR: This work provides a broad overview of how histone methylation is regulated and leads to biological outcomes and suggests its links to disease and ageing and possibly to transmission of traits across generations are illustrated.
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Genomic Maps and Comparative Analysis of Histone Modifications in Human and Mouse
Bradley E. Bernstein,Bradley E. Bernstein,Bradley E. Bernstein,Michael Kamal,Kerstin Lindblad-Toh,Stefan Bekiranov,Dione K. Bailey,Dana J. Huebert,Dana J. Huebert,Scott McMahon,Scott McMahon,Elinor K. Karlsson,Edward J. Kulbokas,Thomas R. Gingeras,Stuart L. Schreiber,Stuart L. Schreiber,Eric S. Lander,Eric S. Lander +17 more
TL;DR: Methylation patterns at orthologous loci are strongly conserved between human and mouse even though many methylated sites do not show sequence conservation notably higher than background, which suggests that the DNA elements that direct the methylation represent only a small fraction of the region or lie at some distance from the site.
References
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TL;DR: A procedure for preparing extracts from nuclei of human tissue culture cells that directs accurate transcription initiation in vitro from class II promoters, including tRNA and Ad 2 VA, is developed.
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