T
Tatyana Gindin
Researcher at Columbia University Medical Center
Publications - 22
Citations - 1117
Tatyana Gindin is an academic researcher from Columbia University Medical Center. The author has contributed to research in topics: Leukemia & Myeloid. The author has an hindex of 13, co-authored 21 publications receiving 918 citations. Previous affiliations of Tatyana Gindin include Columbia University & Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
Structural repertoire of HIV-1-neutralizing antibodies targeting the CD4 supersite in 14 donors
Tongqing Zhou,Rebecca M. Lynch,Lei Chen,Priyamvada Acharya,Xueling Wu,Nicole A. Doria-Rose,M. Gordon Joyce,Daniel Lingwood,Cinque Soto,Robert T. Bailer,Michael J. Ernandes,Rui Kong,Nancy S. Longo,Mark K. Louder,Krisha McKee,Sijy O'Dell,Stephen D. Schmidt,Lillian Tran,Zhongjia Yang,Aliaksandr Druz,Timothy S. Luongo,Stephanie Moquin,Sanjay Srivatsan,Yongping Yang,Baoshan Zhang,Anqi Zheng,Marie Pancera,Tatsiana Kirys,Ivelin S. Georgiev,Tatyana Gindin,Hung-Pin Peng,An-Suei Yang,James C. Mullikin,Matthew D. Gray,Leonidas Stamatatos,Dennis R. Burton,Dennis R. Burton,Wayne C. Koff,Myron S. Cohen,Barton F. Haynes,Joseph P. Casazza,Mark Connors,Davide Corti,Antonio Lanzavecchia,Quentin J. Sattentau,Robin A. Weiss,Anthony P. West,Pamela J. Bjorkman,Johannes F. Scheid,Michel C. Nussenzweig,Michel C. Nussenzweig,Lawrence Shapiro,Lawrence Shapiro,John R. Mascola,Peter D. Kwong +54 more
TL;DR: The repertoire for effective recognition of the CD4 supersite thus comprises antibodies with distinct paratopes arrayed about two optimal geometric orientations, one achieved by CDR H3 ontogenies and the other achieved by VH-gene-restricted ontogeny.
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Comprehensive MR Imaging Protocol for Stroke Management: Tissue Sodium Concentration as a Measure of Tissue Viability in Nonhuman Primate Studies and in Clinical Studies
TL;DR: Tissue sodium concentration provides a sensitive measure of tissue viability that is complementary to the diagnostic role of diffusion and perfusion imaging for ischemic insult.
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Quantitative tissue sodium concentration mapping of the growth of focal cerebral tumors with sodium magnetic resonance imaging.
TL;DR: The 23Na MRI method measured focally increased TSC values in tumors that were equivalent statistically to the destructive 22Na RDA method, and provided a quantitative means with which to monitor focal brain tumor growth.
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Unfolded state of polyalanine is a segmented polyproline II helix.
TL;DR: It is found that under near physiological conditions the configurational ensemble of the unfolded state of the simplest protein structure, polyalanine α‐helix, cannot be described by the commonly used Flory random coil model, in which configuration probabilities are derived from conformational preferences of individual residues.
Journal ArticleDOI
Free Energy Perturbation Calculation of Relative Binding Free Energy between Broadly Neutralizing Antibodies and the gp120 Glycoprotein of HIV-1
Anthony J. Clark,Tatyana Gindin,Baoshan Zhang,Lingle Wang,Robert Abel,Colleen S. Murret,Fang Xu,Amy Bao,Nina J. Lu,Tongqing Zhou,Peter D. Kwong,Lawrence Shapiro,Barry Honig,Richard A. Friesner +13 more
TL;DR: A systematic free energy perturbation protocol is described and the binding affinities between the gp120 envelope glycoprotein of HIV-1 and three broadly neutralizing antibodies (bNAbs) of the VRC01 class are calculated.