Structural repertoire of HIV-1-neutralizing antibodies targeting the CD4 supersite in 14 donors
Tongqing Zhou,Rebecca M. Lynch,Lei Chen,Priyamvada Acharya,Xueling Wu,Nicole A. Doria-Rose,M. Gordon Joyce,Daniel Lingwood,Cinque Soto,Robert T. Bailer,Michael J. Ernandes,Rui Kong,Nancy S. Longo,Mark K. Louder,Krisha McKee,Sijy O'Dell,Stephen D. Schmidt,Lillian Tran,Zhongjia Yang,Aliaksandr Druz,Timothy S. Luongo,Stephanie Moquin,Sanjay Srivatsan,Yongping Yang,Baoshan Zhang,Anqi Zheng,Marie Pancera,Tatsiana Kirys,Ivelin S. Georgiev,Tatyana Gindin,Hung-Pin Peng,An-Suei Yang,James C. Mullikin,Matthew D. Gray,Leonidas Stamatatos,Dennis R. Burton,Dennis R. Burton,Wayne C. Koff,Myron S. Cohen,Barton F. Haynes,Joseph P. Casazza,Mark Connors,Davide Corti,Antonio Lanzavecchia,Quentin J. Sattentau,Robin A. Weiss,Anthony P. West,Pamela J. Bjorkman,Johannes F. Scheid,Michel C. Nussenzweig,Michel C. Nussenzweig,Lawrence Shapiro,Lawrence Shapiro,John R. Mascola,Peter D. Kwong +54 more
TLDR
The repertoire for effective recognition of the CD4 supersite thus comprises antibodies with distinct paratopes arrayed about two optimal geometric orientations, one achieved by CDR H3 ontogenies and the other achieved by VH-gene-restricted ontogeny.About:
This article is published in Cell.The article was published on 2015-06-04 and is currently open access. It has received 274 citations till now. The article focuses on the topics: Primary and secondary antibodies & Paratope.read more
Citations
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Journal ArticleDOI
Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design
Dennis R. Burton,Lars Hangartner +1 more
TL;DR: Molecular studies of recombinant Env trimers, alone and in interaction with bnAbs, are providing new insights that are fueling the development and testing of promising immunogens aimed at the elicitation of bnabs.
Journal ArticleDOI
Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection
Rebecca M. Lynch,Eli Boritz,Emily E. Coates,Adam DeZure,Patrick J Madden,Pamela Costner,Mary E. Enama,Sarah H. Plummer,LaSonji A. Holman,Cynthia S. Hendel,Ingelise J. Gordon,Joseph P. Casazza,Michelle Conan-Cibotti,Stephen A. Migueles,Randall Tressler,Robert T. Bailer,Adrian B. McDermott,Sandeep Narpala,Sijy O'Dell,Gideon Wolf,Jeffrey D. Lifson,Brandie A. Freemire,Robert J. Gorelick,Janardan P. Pandey,Sarumathi Mohan,Nicolas Chomont,Rémi Fromentin,Tae-Wook Chun,Anthony S. Fauci,Richard M. Schwartz,Richard A. Koup,Daniel C. Douek,Zonghui Hu,Edmund V. Capparelli,Barney S. Graham,John R. Mascola,Julie E. Ledgerwood,Vrc Study Team +37 more
TL;DR: A single infusion of mAb VRC01 significantly decreased plasma viremia and preferentially suppressed neutralization-sensitive virus strains, demonstrating the virological effect of this neutralizing antibody and highlighting the need for combination strategies to maintain virus suppression.
Journal ArticleDOI
HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen.
Joseph G. Jardine,Daniel W. Kulp,Colin Havenar-Daughton,Anita Sarkar,Bryan Briney,Devin Sok,Fabian Sesterhenn,June Ereño-Orbea,Oleksandr Kalyuzhniy,Isaiah Deresa,Isaiah Deresa,Xiaozhen Hu,Skye Spencer,Meaghan Jones,Erik Georgeson,Yumiko Adachi,Michael Kubitz,Allan C. deCamp,Jean-Philippe Julien,Ian A. Wilson,Dennis R. Burton,Shane Crotty,Shane Crotty,Shane Crotty,William R. Schief +24 more
TL;DR: An immunogen that could engage B cells from HIV-uninfected individuals that express the germline versions of the immunoglobulin genes harbored by a particular class of bNAbs is engineered, suggesting that the immunogen is a promising candidate for a human vaccine prime.
Journal ArticleDOI
Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B and G
Guillaume Stewart-Jones,Cinque Soto,Thomas Lemmin,Thomas Lemmin,Gwo-Yu Chuang,Aliaksandr Druz,Rui Kong,Paul V. Thomas,Kshitij Wagh,Tongqing Zhou,Anna-Janina Behrens,Tatsiana Bylund,Chang W. Choi,Jack R. Davison,Ivelin S. Georgiev,M. Gordon Joyce,Young Do Kwon,Marie Pancera,Justin Taft,Yongping Yang,Baoshan Zhang,Sachin S. Shivatare,Vidya S. Shivatare,Chang-Chun D Lee,Chung-Yi Wu,Carole A. Bewley,Dennis R. Burton,Dennis R. Burton,Wayne C. Koff,Mark Connors,Max Crispin,Ulrich Baxa,Bette T. Korber,Chi-Huey Wong,Chi-Huey Wong,John R. Mascola,Peter D. Kwong +36 more
TL;DR: Crystallized fully glycosylated Env trimers from clades A, B, and G reveal a diversity in oligosaccharide affinity and a requirement for accommodating glycans among known broadly neutralizing antibodies that target the glycan-shielded trimer.
Journal ArticleDOI
Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite.
Gabriele Cerutti,Yicheng Guo,Tongqing Zhou,Jason Gorman,Myungjin Lee,Micah Rapp,Eswar R. Reddem,Jian Yu,Fabiana Bahna,Jude Bimela,Yaoxing Huang,Phinikoula S. Katsamba,Lihong Liu,Manoj S. Nair,Reda Rawi,Adam S. Olia,Pengfei Wang,Baoshan Zhang,Gwo-Yu Chuang,David D. Ho,Zizhang Sheng,Peter D. Kwong,Peter D. Kwong,Lawrence Shapiro +23 more
TL;DR: In this article, the NTD-directed neutralizing antibody targets a single supersite, formed primarily by a mobile β-hairpin and several flexible loops, and the largest glycan-free surface of NTD facing away from the viral membrane.
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