M
Michael J. Ernandes
Researcher at National Institutes of Health
Publications - 5
Citations - 1390
Michael J. Ernandes is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Somatic hypermutation & Antibody. The author has an hindex of 5, co-authored 5 publications receiving 1193 citations. Previous affiliations of Michael J. Ernandes include Boston Children's Hospital & Harvard University.
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Journal ArticleDOI
Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies.
Nicole A. Doria-Rose,Chaim A. Schramm,Jason Gorman,Penny L. Moore,Jinal N. Bhiman,Brandon J. DeKosky,Michael J. Ernandes,Ivelin S. Georgiev,Helen J. Kim,Marie Pancera,Ryan P. Staupe,Han Altae-Tran,Robert T. Bailer,Ema T. Crooks,Albert Cupo,Aliaksandr Druz,Nigel Garrett,Kam Hon Hoi,Rui Kong,Mark K. Louder,Nancy S. Longo,Krisha McKee,Molati Nonyane,Sijy O'Dell,Ryan S. Roark,Rebecca S. Rudicell,Stephen D. Schmidt,Daniel J. Sheward,Cinque Soto,Constantinos Kurt Wibmer,Yongping Yang,Zhenhai Zhang,Nisc Comparative Sequencing,James C. Mullikin,James M. Binley,Rogier W. Sanders,Ian A. Wilson,John P. Moore,Andrew B. Ward,George Georgiou,Carolyn Williamson,Salim S. Abdool Karim,Lynn Morris,Peter D. Kwong,Lawrence Shapiro,John R. Mascola +45 more
TL;DR: HIV-1 V1V2-directed neutralizing antibodies can develop relatively rapidly through initial selection of B cells with a long CDR H3, and limited subsequent somatic hypermutation, and provide important insights relevant to HIV-1 vaccine development.
Journal ArticleDOI
Structural repertoire of HIV-1-neutralizing antibodies targeting the CD4 supersite in 14 donors
Tongqing Zhou,Rebecca M. Lynch,Lei Chen,Priyamvada Acharya,Xueling Wu,Nicole A. Doria-Rose,M. Gordon Joyce,Daniel Lingwood,Cinque Soto,Robert T. Bailer,Michael J. Ernandes,Rui Kong,Nancy S. Longo,Mark K. Louder,Krisha McKee,Sijy O'Dell,Stephen D. Schmidt,Lillian Tran,Zhongjia Yang,Aliaksandr Druz,Timothy S. Luongo,Stephanie Moquin,Sanjay Srivatsan,Yongping Yang,Baoshan Zhang,Anqi Zheng,Marie Pancera,Tatsiana Kirys,Ivelin S. Georgiev,Tatyana Gindin,Hung-Pin Peng,An-Suei Yang,James C. Mullikin,Matthew D. Gray,Leonidas Stamatatos,Dennis R. Burton,Dennis R. Burton,Wayne C. Koff,Myron S. Cohen,Barton F. Haynes,Joseph P. Casazza,Mark Connors,Davide Corti,Antonio Lanzavecchia,Quentin J. Sattentau,Robin A. Weiss,Anthony P. West,Pamela J. Bjorkman,Johannes F. Scheid,Michel C. Nussenzweig,Michel C. Nussenzweig,Lawrence Shapiro,Lawrence Shapiro,John R. Mascola,Peter D. Kwong +54 more
TL;DR: The repertoire for effective recognition of the CD4 supersite thus comprises antibodies with distinct paratopes arrayed about two optimal geometric orientations, one achieved by CDR H3 ontogenies and the other achieved by VH-gene-restricted ontogeny.
Journal ArticleDOI
New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency
Nicole A. Doria-Rose,Jinal N. Bhiman,Jinal N. Bhiman,Ryan S. Roark,Chaim A. Schramm,Jason Gorman,Gwo-Yu Chuang,Marie Pancera,Evan M. Cale,Michael J. Ernandes,Mark K. Louder,Mangaiarkarasi Asokan,Robert T. Bailer,Aliaksandr Druz,Isabella R. Fraschilla,Nigel Garrett,Marissa C. Jarosinski,Rebecca M. Lynch,Krisha McKee,Sijy O'Dell,Amarendra Pegu,Stephen D. Schmidt,Ryan P. Staupe,Matthew S. Sutton,Keyun Wang,Constantinos Kurt Wibmer,Constantinos Kurt Wibmer,Barton F. Haynes,Salim Abdool-Karim,Salim Abdool-Karim,Lawrence Shapiro,Peter D. Kwong,Penny L. Moore,Penny L. Moore,Penny L. Moore,Lynn Morris,Lynn Morris,Lynn Morris,John R. Mascola +38 more
TL;DR: The results highlight the ongoing evolution within a single antibody lineage and describe more potent and broadly neutralizing members with potential clinical utility, particularly in areas where clade C is prevalent.
Journal ArticleDOI
Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design
Jason Gorman,Cinque Soto,Max M. Yang,Thaddeus M. Davenport,Miklos Guttman,Robert T. Bailer,Michael Chambers,Gwo-Yu Chuang,Brandon J. DeKosky,Brandon J. DeKosky,Nicole A. Doria-Rose,Aliaksandr Druz,Michael J. Ernandes,Ivelin S. Georgiev,Marissa C. Jarosinski,M. Gordon Joyce,Thomas Lemmin,Sherman Leung,Mark K. Louder,Jonathan R. McDaniel,Sandeep Narpala,Marie Pancera,Jonathan Stuckey,Xueling Wu,Yongping Yang,Baoshan Zhang,Tongqing Zhou,Nisc Comparative Sequencing Program,James C. Mullikin,Ulrich Baxa,George Georgiou,Adrian B. McDermott,Mattia Bonsignori,Barton F. Haynes,Penny L. Moore,Penny L. Moore,Penny L. Moore,Lynn Morris,Lynn Morris,Lynn Morris,Kelly K. Lee,Lawrence Shapiro,Lawrence Shapiro,John R. Mascola,Peter D. Kwong +44 more
TL;DR: The ontogeny-based design of vaccine antigens described here may provide a general means for eliciting antibodies of a desired class, as well as an extended class, for which V1V2-directed bNAbs form an 'extended class'.
Journal ArticleDOI
Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain
Donald D. Raymond,Shaun M Stewart,Jiwon Lee,Jack Ferdman,Goran Bajic,Khoi T. Do,Michael J. Ernandes,Michael J. Ernandes,Pirada Suphaphiphat,Ethan C. Settembre,Philip R. Dormitzer,Giuseppe Del Giudice,Oretta Finco,Tae Hyun Kang,Gregory C. Ippolito,George Georgiou,Thomas B. Kepler,Barton F. Haynes,M. Anthony Moody,Hua-Xin Liao,Aaron G. Schmidt,Stephen C. Harrison,Stephen C. Harrison +22 more
TL;DR: When vaccines produced from strains that are never passaged in avian cells become widely available, they may prove more capable of eliciting RBS-directed, broadly neutralizing antibodies than those produced from egg-adapted viruses, extending the established benefits of current seasonal influenza immunizations.