T
Thomas D. Schmittgen
Researcher at University of Florida
Publications - 119
Citations - 177830
Thomas D. Schmittgen is an academic researcher from University of Florida. The author has contributed to research in topics: microRNA & Cancer. The author has an hindex of 48, co-authored 111 publications receiving 150512 citations. Previous affiliations of Thomas D. Schmittgen include University of Southern California & University of Oklahoma.
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Journal ArticleDOI
Expression Profiling Identifies the Noncoding Processed Transcript of HNRNPU with Proliferative Properties in Pancreatic Ductal Adenocarcinoma.
Dhruvitkumar S. Sutaria,Dhruvitkumar S. Sutaria,Jinmai Jiang,Ana Clara P. Azevedo-Pouly,Eun Joo Lee,Megan R. Lerner,Daniel J. Brackett,Jo Vandesompele,Pieter Mestdagh,Thomas D. Schmittgen +9 more
TL;DR: The expression of HNRNPU processed transcript was increased in PDAC cell lines compared to noncancerous pancreatic cell lines; knockdown of this lncRNA further reduces proliferation and invasion/migration of pancreatic carcinoma cells.
Journal ArticleDOI
Loss of RE-1 silencing transcription factor accelerates exocrine damage from pancreatic injury.
Julie K. Bray,Ola A. Elgamal,Jinmai Jiang,Lais S. Wright,Dhruvitkumar S. Sutaria,Mohamed Badawi,Madeline G. Borcyk,Xiuli Liu,Kristianna Fredenburg,Martha Campbell-Thompson,Thomas D. Schmittgen +10 more
TL;DR: REST has a novel protective role against pancreatic tissue damage by acting as a regulator of exocrine cell identity in mice treated with cholecystokinin analog caerulein.
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In vitro immunotoxicity assessment of culture-derived extracellular vesicles in human monocytes
Lucia E. Rosas,Ola A. Elgamal,Xiaokui Mo,Mitch A. Phelps,Thomas D. Schmittgen,Tracey L. Papenfuss +5 more
TL;DR: It is suggested that, although HEK293T-derived EV are efficiently internalized by human monocytic cells, they do not exert a cytotoxic effect or alter phagocytic efficiency on the cell lines evaluated.
Journal ArticleDOI
Knockout of Acinar Enriched microRNAs in Mice Promote Duct Formation But Not Pancreatic Cancer.
Dhruvitkumar S. Sutaria,Jinmai Jiang,Ana Clara Azevedo-Pouly,Lais S. Wright,Julie A. Bray,Kristianna Fredenburg,Xiuli Liu,Jun Lu,Carolina Torres,Georgina Mancinelli,Paul J. Grippo,Vincenzo Coppola,Thomas D. Schmittgen +12 more
TL;DR: The data does not support a tumor suppressor role for miR-216a, mi-216b or mi-217 in PDAC and emphasizes the need for phenotypic evaluation of miRNAs in complex in vivo models beyond that performed using cell culture.
Journal ArticleDOI
Studies on the Antileishmanial Mechanism of Action of the Arylimidamide DB766: Azole Interactions and Role of CYP5122A1
Trupti Pandharkar,Xiaohua Zhu,Radhika Mathur,Jinmai Jiang,Thomas D. Schmittgen,Chandrima Shaha,Karl A. Werbovetz +6 more
TL;DR: These studies implicate CYP5122A1 in the antileishmanial action of the AIAs and suggest that DB766-azole combinations are potential candidates for the development of synergistic antileishingmanial therapy.