T
Thomas D. Schmittgen
Researcher at University of Florida
Publications - 119
Citations - 177830
Thomas D. Schmittgen is an academic researcher from University of Florida. The author has contributed to research in topics: microRNA & Cancer. The author has an hindex of 48, co-authored 111 publications receiving 150512 citations. Previous affiliations of Thomas D. Schmittgen include University of Southern California & University of Oklahoma.
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Journal ArticleDOI
Systematic evaluation of microRNA processing patterns in tissues, cell lines, and tumors.
Eun Joo Lee,Myungwon Baek,Yuriy Gusev,Daniel J. Brackett,Gerard J. Nuovo,Thomas D. Schmittgen +5 more
TL;DR: The data demonstrate that a large number of miRNAs are transcribed but are not processed to the mature miRNA, and in situ hybridization analysis demonstrates that these miRNA precursors are retained in the nucleus.
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MicroRNAs modulate the chemosensitivity of tumor cells
Paul E. Blower,Ji Hyun Chung,Joseph S. Verducci,Shili Lin,Jong Kook Park,Zunyan Dai,Chang Gong Liu,Thomas D. Schmittgen,William C. Reinhold,Carlo M. Croce,John N. Weinstein,Wolfgang Sadee +11 more
TL;DR: A substantial role for microRNAs in anticancer drug response is supported, suggesting novel potential approaches to the improvement of chemotherapy and comparing drug potencies with microRNA expression profiles across the entire NCI-60 panel.
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Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells
Xiaohua Zhu,Mohamed Badawi,Steven M. Pomeroy,Dhruvitkumar S. Sutaria,Zhiliang Xie,Alice Baek,Jinmai Jiang,Ola A. Elgamal,Xiaokui Mo,Krista M. D. La Perle,Jeffrey J. Chalmers,Thomas D. Schmittgen,Mitch A. Phelps +12 more
TL;DR: This study provides a framework for assessment of immunogenicity and toxicity that will be required as EVs from varying cell sources are tested within numerous animal models and eventually in humans.
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Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL/6 mice.
Bo Wang,Sarmila Majumder,Gerard J. Nuovo,Huban Kutay,Stefano Volinia,Tushar Patel,Thomas D. Schmittgen,Carlo M. Croce,Kalpana Ghoshal,Samson T. Jacob +9 more
TL;DR: In this article, the authors identify 30 hepatic microRNAs that are dysregulated at early stages of feeding C57BL/6 mice choline deficient and amino acid defined (CDAA) diet that is known to promote NASH-induced hepatocarcinogenesis after 84 weeks.
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Antisense Inhibition of microRNA-21 or -221 Arrests Cell Cycle, Induces Apoptosis, and Sensitizes the Effects of Gemcitabine in Pancreatic Adenocarcinoma
TL;DR: It is demonstrated that antisense to niR-21 and miR-221 results in significant cell killing under various conditions and that antisensing oligonucleotides targeted to miRNA represents a potential new therapy for pancreatic cancer.