Thomas D. Schmittgen

TL;DR: By direct comparison with real-time reverse transcriptase (RT)-PCR, RT in situ PCR, and standard in situ hybridization using a locked nucleic acid (LNA) probe, it was evident that the ultramer extension method detects only the mature miRNA, is easier to optimize, results generally in a stronger signal, and is much less expensive than the LNA probe method currently used.

TL;DR: Cholangiocarcinoma has a distinct miR profile from pancreatic adenocarc inoma, and discrimination between these two tumor types may be possible with as few as seven miRs.

TL;DR: In this paper, miR-221 was found to directly or indirectly regulate CD44 expression in hepatocellular carcinoma (HCC) cell lines and tumors, but a connection between the two has not been identified.

TL;DR: A global increase in expression of T-UCRs is reported in both human and mouse PDAC, suggesting a similar mechanism of transcriptional upregulation for T- UCRs in PDAC.

TL;DR: In resected CC, the concomitant dysregulation of bothmiR-151-3p and miR-126 was the factor related to the greatest improvement in overall survival and further analysis of the targets of these miRNAs may yield potential therapeutic targets or prognostic biomarkers.