T
Thomas H. Clarke
Researcher at J. Craig Venter Institute
Publications - 14
Citations - 649
Thomas H. Clarke is an academic researcher from J. Craig Venter Institute. The author has contributed to research in topics: Microbiome & Medicine. The author has an hindex of 7, co-authored 11 publications receiving 341 citations.
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Journal ArticleDOI
Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease
Yi Duan,Yi Duan,Cristina Llorente,Cristina Llorente,Sonja Lang,Katharina Brandl,Huikuan Chu,Lu Jiang,Lu Jiang,Richard C. White,Thomas H. Clarke,Kevin Nguyen,Manolito Torralba,Yan Shao,Jinyuan Liu,Adriana Hernandez-Morales,Lauren Lessor,Imran R Rahman,Yukiko Miyamoto,Melissa Ly,Bei Gao,Weizhong Sun,Roman Kiesel,Felix Hutmacher,Suhan Lee,Meritxell Ventura-Cots,Francisco Bosques-Padilla,Elizabeth C. Verna,Juan G. Abraldes,Robert S. Brown,Victor Vargas,José Altamirano,Juan Caballería,Debbie L. Shawcross,Samuel B. Ho,Samuel B. Ho,Alexandre Louvet,Michael R. Lucey,Philippe Mathurin,Guadalupe Garcia-Tsao,Ramon Bataller,Xin M. Tu,Lars Eckmann,Wilfred A. van der Donk,Ry Young,Trevor D. Lawley,Peter Stärkel,David T. Pride,Derrick E. Fouts,Bernd Schnabl,Bernd Schnabl +50 more
TL;DR: It is shown that bacteriophages can specifically target cytolytic E. faecalis, which provides a method for precisely editing the intestinal microbiota, and is linked with more severe clinical outcomes and increased mortality in patients with alcoholic hepatitis.
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Integrating the microbiome as a resource in the forensics toolkit.
TL;DR: Information is summarized on the current status of microbiome research as applies to the forensic field, the mathematical models used to make predictions, and the possible legal and practical difficulties that can limit the application of microbiomes in forensic science.
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Enterobacter hormaechei subsp. hoffmannii subsp. nov., Enterobacter hormaechei subsp. xiangfangensis comb. nov., Enterobacter roggenkampii sp. nov., and Enterobacter muelleri is a later heterotypic synonym of Enterobacter asburiae based on computational analysis of sequenced Enterobacter genomes.
TL;DR: The phylogeny of the Enterobacter genus, particularly the cloacae complex, was re-evaluated based on the type strain genome sequences and all other available Enterobacteria genomes in RefSeq.
Journal ArticleDOI
Spatial and Environmental Variation of the Human Hair Microbiota.
Lauren M. Brinkac,Thomas H. Clarke,Harinder Singh,Chris Greco,Andres Gomez,Manolito Torralba,Bryan C. Frank,Karen E. Nelson +7 more
TL;DR: The results suggest that there are distinct differences between the microbial communities identified on hair shafts originating from different parts of the body and demonstrate that the hair microbiota varies by geographical origin and has the potential to be used to predict the source location of the hair.
Journal ArticleDOI
A comprehensive and contemporary "snapshot" of β-lactamases in carbapenem resistant Acinetobacter baumannii.
Andrea M. Hujer,Kristine M. Hujer,David A. Leonard,Rachel A. Powers,Bradley J. Wallar,Andrew R Mack,Magdalena A. Taracila,Philip N. Rather,Paul G. Higgins,Fabio Prati,Emilia Caselli,Steven H. Marshall,Thomas H. Clarke,Christopher Greco,Pratap Venepally,Lauren Brinkac,Barry N. Kreiswirth,Derrick E. Fouts,Robert A. Bonomo +18 more
TL;DR: WGS on 98 carbapenem-resistant A. baumannii isolates found that in most isolates, an acquired blaOXA carbapenenemase was found in addition to the intrinsic BlaOxA allele, and the most commonly found alleel was blAOXA-23 (n=78/98).