T
Thomas J. Pucadyil
Researcher at Indian Institute of Science Education and Research, Pune
Publications - 68
Citations - 3856
Thomas J. Pucadyil is an academic researcher from Indian Institute of Science Education and Research, Pune. The author has contributed to research in topics: Dynamin & Membrane. The author has an hindex of 31, co-authored 61 publications receiving 3306 citations. Previous affiliations of Thomas J. Pucadyil include Centre for Cellular and Molecular Biology & Indian Institute of Science.
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Role of cholesterol in the function and organization of G-protein coupled receptors.
TL;DR: A novel mechanism by which membrane cholesterol could affect structure and function of GPCRs is proposed and it is envisaged that there could be specific/nonannular cholesterol binding site(s) in the serotonin(1A) receptor.
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Real-time Visualization of Dynamin-catalyzed Membrane Fission and Vesicle Release
TL;DR: Self-limited assemblies of dynamin generated in the constant presence of GTP catalyze membrane fission, arguing against models in which fission is mediated by concerted and global GTP-driven conformational changes.
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Cholesterol modulates ligand binding and G-protein coupling to serotonin1A receptors from bovine hippocampus
TL;DR: Evidence is provided, for the first time, that cholesterol is necessary for ligand binding and G-protein coupling of this important neurotransmitter receptor and could have significant implications in understanding the influence of the membrane lipid environment on the activity and signal transduction of other G- protein-coupled transmembrane receptors.
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The Serotonin1A Receptor: A Representative Member of the Serotonin Receptor Family
TL;DR: The ligand binding activity and G-protein coupling of the receptor is modulated by membrane cholesterol thereby indicating the requirement of cholesterol in maintaining the receptor organization and function, raises important questions on the role of membrane lipids and domains in the function of this receptor.
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The 2018 biomembrane curvature and remodeling roadmap.
Patricia Bassereau,Patricia Bassereau,Rui Jin,Tobias Baumgart,Markus Deserno,Rumiana Dimova,Vadim A. Frolov,Vadim A. Frolov,Pavel V. Bashkirov,Helmut Grubmüller,Reinhard Jahn,H. Jelger Risselada,Ludger Johannes,Michael M. Kozlov,Reinhard Lipowsky,Thomas J. Pucadyil,Wade F. Zeno,Jeanne C. Stachowiak,Dimitrios Stamou,Artù Breuer,Line Lauritsen,Camille Simon,Camille Simon,Cécile Sykes,Cécile Sykes,Gregory A. Voth,Thomas R. Weikl +26 more
TL;DR: The 2018 Biomembrane Curvature and Remodeling Roadmap of Journal of Physics D: Applied Physics addresses the need for clarity and is intended to provide guidance both for students who have just entered the field as well as established scientists who would like to improve their orientation within this fascinating area.