T
Thomas Lion
Researcher at Medical University of Vienna
Publications - 218
Citations - 9673
Thomas Lion is an academic researcher from Medical University of Vienna. The author has contributed to research in topics: Transplantation & Leukemia. The author has an hindex of 48, co-authored 210 publications receiving 8709 citations. Previous affiliations of Thomas Lion include University of Edinburgh & Boston Children's Hospital.
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Journal ArticleDOI
Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time' quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR) - a Europe against cancer program
Emmanuel Beillard,Niels Pallisgaard,V H J van der Velden,Wanli Bi,R Dee,E van der Schoot,Eric Delabesse,E Macintyre,Enrico Gottardi,Giuseppe Saglio,F Watzinger,Thomas Lion,J. J. M. Van Dongen,Peter Hokland,Jean Gabert +14 more
TL;DR: The ABL gene is proposed to be used as CG for RQ-PCR-based diagnosis and MRD detection in leukemic patients and these data are not only eligible for quantifying of fusion gene transcripts, but also for the quantification of aberrantly expressed genes.
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Adenovirus Infections in Immunocompetent and Immunocompromised Patients
TL;DR: The present review summarizes the recent progress in the understanding and management of HAdV infections and underscores the urgent need for highly effective treatment modalities lacking major side effects.
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Safe adoptive transfer of virus-specific T-cell immunity for the treatment of systemic adenovirus infection after allogeneic stem cell transplantation
Tobias Feuchtinger,Susanne Matthes-Martin,Celine Richard,Thomas Lion,Monika Führer,Klaus Hamprecht,Rupert Handgretinger,Christina Peters,Friedhelm R. Schuster,Robert Beck,Michael Schumm,Ramin Lotfi,Gerhard Jahn,Peter Lang +13 more
TL;DR: In conclusion, induction of a specific T‐cell response through adoptive transfer was feasible and effective, and when performed early in the course of infection, adoptive T‐ cell transfer may protect from HAdV‐related complications.
Journal ArticleDOI
Molecular monitoring of adenovirus in peripheral blood after allogeneic bone marrow transplantation permits early diagnosis of disseminated disease.
Thomas Lion,Rosi Baumgartinger,F Watzinger,Susanne Matthes-Martin,Magdalena Suda,Sandra Preuner,Barbara Futterknecht,Anita Lawitschka,Christina Peters,Ulrike Pötschger,Helmut Gadner +10 more
TL;DR: Real-time polymerase chain reaction (PCR) assays permitting sensitive detection and quantification of all 51 currently known human AdV serotypes are established, paving the way for early diagnosis of invasive AdV infection in all instances.
Journal ArticleDOI
Real-Time Quantitative PCR Assays for Detection and Monitoring of Pathogenic Human Viruses in Immunosuppressed Pediatric Patients
F Watzinger,Magdalena Suda,S Preuner,R. Baumgartinger,K. Ebner,Lenka Baskova,Hubert G. M. Niesters,Anita Lawitschka,Thomas Lion +8 more
TL;DR: It is demonstrated that, in immunosuppressed patients with invasive virus infections, surveillance by the assays described may permit detection of increasing viral load several days to weeks prior to the onset of clinical symptoms.