N
Niels Pallisgaard
Researcher at Aarhus University
Publications - 101
Citations - 5900
Niels Pallisgaard is an academic researcher from Aarhus University. The author has contributed to research in topics: KRAS & Colorectal cancer. The author has an hindex of 31, co-authored 91 publications receiving 5314 citations. Previous affiliations of Niels Pallisgaard include Roskilde Sygehus & Aarhus University Hospital.
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Journal ArticleDOI
Standardization and quality control studies of ‘real-time’ quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia – A Europe Against Cancer Program
Jean Gabert,Emmanuel Beillard,V H J van der Velden,Wanli Bi,David Grimwade,Niels Pallisgaard,Gisela Barbany,Giovanni Cazzaniga,Jean Michel Cayuela,Hélène Cavé,Fabrizio Pane,J. L. E. Aerts,D De Micheli,X Thirion,V Pradel,Marcos González,Susanne Viehmann,Maria Malec,Giuseppe Saglio,J. J. M. Van Dongen +19 more
TL;DR: The development of standardized protocols for RQ-PCR analysis of FG transcripts provides a milestone for molecular determination of MRD levels and is likely to prove invaluable to the management of patients entered into multicenter therapeutic trials.
Journal ArticleDOI
Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time' quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR) - a Europe against cancer program
Emmanuel Beillard,Niels Pallisgaard,V H J van der Velden,Wanli Bi,R Dee,E van der Schoot,Eric Delabesse,E Macintyre,Enrico Gottardi,Giuseppe Saglio,F Watzinger,Thomas Lion,J. J. M. Van Dongen,Peter Hokland,Jean Gabert +14 more
TL;DR: The ABL gene is proposed to be used as CG for RQ-PCR-based diagnosis and MRD detection in leukemic patients and these data are not only eligible for quantifying of fusion gene transcripts, but also for the quantification of aberrantly expressed genes.
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Analysis of circulating tumour DNA to monitor disease burden following colorectal cancer surgery
Thomas Reinert,Lone V. Schøler,Rune Thomsen,Heidi Tobiasen,Søren Vang,Iver Nordentoft,Philippe Lamy,Anne Sofie Kannerup,Frank Viborg Mortensen,Katrine Stribolt,Stephen Hamilton-Dutoit,Hans Jørgen Nielsen,Søren Laurberg,Niels Pallisgaard,Jakob Skou Pedersen,Torben F. Ørntoft,Claus L. Andersen +16 more
TL;DR: Assessment of ctDNA is a non-invasive, exquisitely specific and highly sensitive approach for monitoring disease load, which has the potential to provide clinically relevant lead times compared with conventional methods.
Journal ArticleDOI
Quantitative Cell-Free DNA, KRAS, and BRAF Mutations in Plasma from Patients with Metastatic Colorectal Cancer during Treatment with Cetuximab and Irinotecan
TL;DR: Quantitative levels of cfDNA and KRAS analysis in plasma are strongly correlated and hold promise of clinical application and Cox analysis confirmed the prognostic importance of bothcfDNA and pmKRAS.
Journal ArticleDOI
Multiplex Reverse Transcription-Polymerase Chain Reaction for Simultaneous Screening of 29 Translocations and Chromosomal Aberrations in Acute Leukemia
Niels Pallisgaard,Peter Hokland,Peter Hokland,Dorthe C. Riishøj,Dorthe C. Riishøj,Bent Pedersen,Bent Pedersen,Poul Jørgensen,Poul Jørgensen +8 more
TL;DR: This multiplex RT-PCR system is an important tool that complements cytogenetic analysis in the up-front screening of acute leukemia patients and should provide a rapid and efficient characterization of leukemia cells, even in situations with sparse patient material.