T
Tiago C. Alves
Researcher at Yale University
Publications - 35
Citations - 1671
Tiago C. Alves is an academic researcher from Yale University. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 18, co-authored 33 publications receiving 1237 citations. Previous affiliations of Tiago C. Alves include University of Coimbra & Howard Hughes Medical Institute.
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Journal ArticleDOI
Targeted Expression of Catalase to Mitochondria Prevents Age-Associated Reductions in Mitochondrial Function and Insulin Resistance
Hui-Young Lee,Cheol Soo Choi,Cheol Soo Choi,Andreas L. Birkenfeld,Tiago C. Alves,François R Jornayvaz,Michael J. Jurczak,Dongyan Zhang,Dong Kyun Woo,Gerald S. Shadel,Warren C. Ladiges,Peter S. Rabinovitch,Janine H. Santos,Kitt Falk Petersen,Varman T. Samuel,Gerald I. Shulman +15 more
TL;DR: Protection from age-induced reduction in mitochondrial function was associated with reduced mitochondrial oxidative damage, preserved mitochondrial respiration and muscle ATP synthesis, and AMP-activated protein kinase-induced mitochondrial biogenesis.
Journal ArticleDOI
FGF-dependent metabolic control of vascular development
Pengchun Yu,Kerstin Wilhelm,Alexandre Dubrac,Joe K. Tung,Tiago C. Alves,Jennifer S. Fang,Yi Xie,Jie Zhu,Zehua Chen,Frederik De Smet,Frederik De Smet,Jiasheng Zhang,Suk-Won Jin,Suk-Won Jin,Lele Sun,Hongye Sun,Richard G. Kibbey,Karen K. Hirschi,Nissim Hay,Peter Carmeliet,Thomas Chittenden,Anne Eichmann,Michael Potente,Michael Simons +23 more
TL;DR: FGF-dependent regulation of endothelial glycolysis is a pivotal process in developmental and adult vascular growth and development and FGF receptor (FGFR) signalling is identified as a critical regulator of vascular development.
Journal ArticleDOI
Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice.
Andreas L. Birkenfeld,Hui-Young Lee,Hui-Young Lee,Fitsum Guebre-Egziabher,Fitsum Guebre-Egziabher,Tiago C. Alves,Tiago C. Alves,Michael J. Jurczak,Michael J. Jurczak,François R Jornayvaz,François R Jornayvaz,Dongyang Zhang,Dongyang Zhang,Jennifer J. Hsiao,Jennifer J. Hsiao,Alejandro Martin-Montalvo,Antje Fischer-Rosinsky,Joachim Spranger,Andreas Pfeiffer,Jens Jordan,Martin F. Fromm,Jörg König,Stefanie Lieske,Christopher M. Carmean,Christopher M. Carmean,David W. Frederick,David W. Frederick,Dirk Weismann,Dirk Weismann,Felix Knauf,Felix Knauf,Pablo M. Irusta,Rafael de Cabo,Stephen L. Helfand,Varman T. Samuel,Varman T. Samuel,Gerald I. Shulman,Gerald I. Shulman +37 more
TL;DR: The authors showed that deletion of the Indy gene in mice (mINDY(-/-) mice reduces hepatocellular ATP/ADP ratio, activates hepatic AMPK, induces PGC-1α, inhibits ACC-2, and reduces SREBP-1c levels.
Journal ArticleDOI
Integrated, Step-Wise, Mass-Isotopomeric Flux Analysis of the TCA Cycle
Tiago C. Alves,Rebecca L. Pongratz,Xiaojian Zhao,Orlando Yarborough,Sam Sereda,Orian S. Shirihai,Gary W. Cline,Graeme F. Mason,Richard G. Kibbey +8 more
TL;DR: MIMOSA measures key metabolic rates from the precursor/product position-specific transfer of (13)C-label between metabolites and has broad applicability to any glucose-oxidizing cell.
Journal ArticleDOI
A role for mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) in the regulation of hepatic gluconeogenesis.
Romana Stark,Fitsum Guebre-Egziabher,Xiaojian Zhao,Colleen N. Feriod,Jianying Dong,Tiago C. Alves,Simona Ioja,Rebecca L. Pongratz,Sanjay Bhanot,Michael Roden,Gary W. Cline,Gerald I. Shulman,Richard G. Kibbey +12 more
TL;DR: PEPCK-M has a direct role in fasted and fed glucose homeostasis, and this mitochondrial GTP-dependent pathway should be reconsidered for its involvement in both normal and diabetic metabolism.