T
Tiansen Li
Researcher at National Institutes of Health
Publications - 113
Citations - 10658
Tiansen Li is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Retinitis pigmentosa & Retinal degeneration. The author has an hindex of 54, co-authored 112 publications receiving 9789 citations. Previous affiliations of Tiansen Li include Harvard University & Massachusetts Eye and Ear Infirmary.
Papers
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Journal ArticleDOI
Cyclin D1 provides a link between development and oncogenesis in the retina and breast
Piotr Sicinski,Joana Liu Donaher,Susan B. Parker,Susan B. Parker,Tiansen Li,Amin Fazeli,Humphrey Gardner,Sandra Z. Haslam,Roderick T. Bronson,Stephen J. Elledge,Robert A. Weinberg +10 more
TL;DR: In adult mutant females, the breast epithelial compartment fails to undergo the massive proliferative changes associated with pregnancy despite normal levels of ovarian steroid hormones, suggesting that steroid-induced proliferation of mammary epithelium during pregnancy may be driven through cyclin D1.
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Elastic fiber homeostasis requires lysyl oxidase-like 1 protein.
Xiao-Qing Liu,Yun Zhao,Jiangang Gao,Basil S. Pawlyk,Barry Starcher,Jeffrey A. Spencer,Hiromi Yanagisawa,J. Zuo,Tiansen Li +8 more
TL;DR: It is shown that mice lacking the protein lysyl oxidase–like 1 (LOXL1) do not deposit normal elastic fibers in the uterine tract post partum and develop pelvic organ prolapse, enlarged airspaces of the lung, loose skin and vascular abnormalities with concomitant tropoelastin accumulation.
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Intrinsic circadian clock of the mammalian retina: importance for retinal processing of visual information.
Kai-Florian Storch,Carlos Paz,James Signorovitch,Elio Raviola,Basil S. Pawlyk,Tiansen Li,Charles J. Weitz +6 more
TL;DR: It is shown that mice lacking Bmal1, a gene required for clock function, had abnormal retinal transcriptional responses to light and defective inner retinal electrical responses toLight, but normal photoreceptor responses to Light and retinas that appeared structurally normal by light and electron microscopy.
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Rescue of Cyclin D1 Deficiency by Knockin Cyclin E
Yan Geng,Wendy Whoriskey,Mary Y. Park,Roderick T. Bronson,René H. Medema,Tiansen Li,Robert A. Weinberg,Piotr Sicinski +7 more
TL;DR: This work has generated a mouse strain in which the coding sequences of the cyclin D1 gene have been deleted and replaced by those of human cyclin E (CCNE), and it is suggested thatcyclin E is the major downstream target of cyclinD1.
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Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis
TL;DR: A differential requirement for cyclin D1-CDK4/6 kinase activity in development versus tumorigenesis is demonstrated and strongly support cyclinD1-dependent Kinase activity as a specific therapeutic target in breast cancer.