T
Tobias J. Weismueller
Researcher at University of Cologne
Publications - 1
Citations - 288
Tobias J. Weismueller is an academic researcher from University of Cologne. The author has contributed to research in topics: Primary sclerosing cholangitis & Genotyping. The author has an hindex of 1, co-authored 1 publications receiving 253 citations.
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Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis
Jimmy Z. Liu,Johannes R. Hov,Trine Folseraas,Eva Ellinghaus,Simon M. Rushbrook,Nadezhda Tsankova Doncheva,Ole A. Andreassen,Rinse K. Weersma,Tobias J. Weismueller,Bertus Eksteen,Pietro Invernizzi,Gideon M. Hirschfield,Daniel Gotthardt,Albert Parés,David Ellinghaus,Tejas Shah,Brian D. Juran,Piotr Milkiewicz,Christian Rust,Christoph Schramm,Tobias Mueller,Brijesh Srivastava,Georgios N. Dalekos,Markus M. Noethen,Stefan Herms,Juliane Winkelmann,Mitja Mitrovic,Felix Braun,Cyriel Y. Ponsioen,Peter J. P. Croucher,Martina Sterneck,Andreas Teufel,Andrew Mason,Janna Saarela,Virpi Leppa,Ruslan Dorfman,Domenico Alvaro,Annarosa Floreani,Suna Onengut-Gumuscu,Stephen S. Rich,Wesley K. Thompson,Andrew J. Schork,Sigrid Næss,Ingo Thomsen,Gabriele Mayr,Inke R. Koenig,Kristian Hveem,Isabelle Cleynen,Javier Gutierrez-Achury,Isis Ricaño-Ponce,David A. van Heel,Einar Bjoernsson,Richard Sandford,Peter R. Durie,Espen Melum,Morten H. Vatn,Mark S. Silverberg,Richard H. Duerr,Leonid Padyukov,Stephan Brand,Miquel Sans,Vito Annese,Jean-Paul Achkar,Kirsten Muri Boberg,Hanns-Ulrich Marschall,Olivier Chazouillères,Christopher L. Bowlus,Cisca Wijmenga,Erik Schrumpf,Severine Vermeire,Mario Albrecht,John D. Rioux,Graeme J.M. Alexander,Annika Bergquist,Judy H. Cho,Stefan Schreiber,Michael P. Manns,Martti Färkkilä,Anders M. Dale,Roger W. Chapman,Konstantinos N. Lazaridis,Andre Franke,Carl A. Anderson,Tom H. Karlsen +83 more
Abstract: Primary sclerosing cholangitis (PSC) is a severe liver disease of unknown etiology leading to fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation. We compared 3,789 PSC cases of European ancestry to 25,079 population controls across 130,422 SNPs genotyped using the Immunochip. We identified 12 genome-wide significant associations outside the human leukocyte antigen (HLA) complex, 9 of which were new, increasing the number of known PSC risk loci to 16. Despite comorbidity with inflammatory bowel disease (IBD) in 72% of the cases, 6 of the 12 loci showed significantly stronger association with PSC than with IBD, suggesting overlapping yet distinct genetic architectures for these two diseases. We incorporated association statistics from 7 diseases clinically occurring with PSC in the analysis and found suggestive evidence for 33 additional pleiotropic PSC risk loci. Together with network analyses, these findings add to the genetic risk map of PSC and expand on the relationship between PSC and other immune-mediated diseases.