G
Gabriele Mayr
Researcher at University of Kiel
Publications - 27
Citations - 4991
Gabriele Mayr is an academic researcher from University of Kiel. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 18, co-authored 25 publications receiving 4561 citations. Previous affiliations of Gabriele Mayr include University of Salzburg & Max Planck Society.
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Journal ArticleDOI
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
Jochen Hampe,Andre Franke,Philip Rosenstiel,Philip Rosenstiel,Andreas Till,Markus Teuber,Klaus Huse,Mario Albrecht,Gabriele Mayr,Francisco M. De La Vega,Jason C Briggs,Simone Günther,Natalie J. Prescott,Clive M. Onnie,Robert Häsler,Bence Sipos,Ulrich R. Fölsch,Thomas Lengauer,Matthias Platzer,Christopher G. Mathew,Michael Krawczak,Stefan Schreiber +21 more
TL;DR: Data suggest that the underlying biological process may be specific to Crohn disease, and that marker rs2241880, a coding SNP (T300A), carries virtually all the disease risk exerted by the ATG16L1 locus.
Journal ArticleDOI
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
Andre Franke,Tobias Balschun,Tom H. Karlsen,Jurgita Sventoraityte,Susanna Nikolaus,Gabriele Mayr,Francisco S. Domingues,Mario Albrecht,Michael Nothnagel,David Ellinghaus,Christian Sina,Clive M. Onnie,Rinse K. Weersma,Pieter C. F. Stokkers,Cisca Wijmenga,Maria Gazouli,David P. Strachan,Wendy L. McArdle,Severine Vermeire,Paul Rutgeerts,Philip Rosenstiel,Michael Krawczak,Morten H. Vatn,Christopher G. Mathew,Stefan Schreiber +24 more
TL;DR: A genome-wide association study with 440,794 SNPs genotyped in 1,167 individuals with UC and 777 healthy controls strongly suggests that defective IL10 function is central to the pathogenesis of the UC subtype of IBD.
Journal ArticleDOI
Structure–function analysis of the NB-ARC domain of plant disease resistance proteins
Gerben van Ooijen,Gabriele Mayr,Mobien M. A. Kasiem,Mario Albrecht,Ben J. C. Cornelissen,Frank L. W. Takken +5 more
TL;DR: A three-dimensional model of the NB-ARC domain of I-2 was built, and it is proposed that the MHD motif fulfils the same function as the sensor II motif found in AAA+ proteins (ATPases associated with diverse cellular activities)-co-ordination of the nucleotide and control of subdomain interactions.
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Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2
Eva Ellinghaus,David Ellinghaus,Philip E. Stuart,Rajan P. Nair,Sophie Debrus,John Verner Raelson,Majid Belouchi,Helene Fournier,Claudia Reinhard,Jun Ding,Yun Li,Trilokraj Tejasvi,Johann E. Gudjonsson,Stefan W. Stoll,John J. Voorhees,Sylviane Lambert,Stephan Weidinger,Stephan Weidinger,Bernadette Eberlein,Manfred Kunz,Proton Rahman,Dafna D. Gladman,Christian Gieger,H.-Erich Wichmann,Tom H. Karlsen,Gabriele Mayr,Mario Albrecht,Dieter Kabelitz,Ulrich Mrowietz,Gonçalo R. Abecasis,James T. Elder,James T. Elder,Stefan Schreiber,Michael Weichenthal,Andre Franke +34 more
TL;DR: A genome-wide association analysis of 2,339,118 SNPs in 472 PsV cases and 1,146 controls from Germany suggests that TRAF3IP2 represents a shared susceptibility for PsV and PsA.
Journal ArticleDOI
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis
Jimmy Z. Liu,Johannes R. Hov,Trine Folseraas,Trine Folseraas,Eva Ellinghaus,Simon M. Rushbrook,Nadezhda Tsankova Doncheva,Ole A. Andreassen,Ole A. Andreassen,Rinse K. Weersma,Tobias J. Weismüller,Bertus Eksteen,Pietro Invernizzi,Gideon M. Hirschfield,Gideon M. Hirschfield,Daniel Gotthardt,Albert Parés,David Ellinghaus,Tejas Shah,Brian D. Juran,Piotr Milkiewicz,Christian Rust,Christoph Schramm,Tobias Müller,Brijesh Srivastava,Georgios N. Dalekos,Markus M. Nöthen,Stefan Herms,Juliane Winkelmann,Mitja Mitrovic,Felix Braun,Cyriel Y. Ponsioen,Peter J. P. Croucher,Martina Sterneck,Andreas Teufel,Andrew Mason,Janna Saarela,Virpi Leppa,Ruslan Dorfman,Domenico Alvaro,Annarosa Floreani,Suna Onengut-Gumuscu,Stephen S. Rich,Wesley K. Thompson,Andrew J. Schork,Sigrid Næss,Sigrid Næss,Ingo Thomsen,Gabriele Mayr,Inke R. König,Kristian Hveem,Isabelle Cleynen,Isabelle Cleynen,Javier Gutierrez-Achury,Isis Ricaño-Ponce,David A. van Heel,Einar Björnsson,Richard Sandford,Peter R. Durie,Espen Melum,Espen Melum,Morten H. Vatn,Morten H. Vatn,Morten H. Vatn,Mark S. Silverberg,Richard H. Duerr,Leonid Padyukov,Stephan Brand,Miquel Sans,Vito Annese,Jean-Paul Achkar,Jean-Paul Achkar,Kirsten Muri Boberg,Kirsten Muri Boberg,Hanns-Ulrich Marschall,Olivier Chazouillères,Christopher L. Bowlus,Cisca Wijmenga,Erik Schrumpf,Erik Schrumpf,Severine Vermeire,Mario Albrecht,John D. Rioux,John D. Rioux,Graeme J.M. Alexander,Annika Bergquist,Judy H. Cho,Stefan Schreiber,Michael P. Manns,Martti Färkkilä,Anders M. Dale,Roger W. Chapman,Konstantinos N. Lazaridis,Andre Franke,Carl A. Anderson,Tom H. Karlsen +95 more
TL;DR: This analysis compared 3,789 PSC cases of European ancestry to 25,079 population controls across 130,422 SNPs genotyped using the Immunochip to identify 12 genome-wide significant associations outside the human leukocyte antigen (HLA) complex, 9 of which were new, increasing the number of known PSC risk loci to 16.