U
Udo Müller
Researcher at Ludwig Maximilian University of Munich
Publications - 10
Citations - 1540
Udo Müller is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: DNA demethylation & DNA. The author has an hindex of 9, co-authored 10 publications receiving 1390 citations. Previous affiliations of Udo Müller include Center for Integrated Protein Science Munich.
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Journal ArticleDOI
Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives
Cornelia G. Spruijt,Felix Gnerlich,Arne H. Smits,Toni Pfaffeneder,Pascal W.T.C. Jansen,Christina Bauer,Martin Münzel,Mirko Wagner,Markus Müller,Fariha Khan,Fariha Khan,H. Christian Eberl,Anneloes Mensinga,Arie B. Brinkman,Konstantin Lephikov,Udo Müller,Jörn Walter,Rolf Boelens,Hugo van Ingen,Heinrich Leonhardt,Thomas Carell,Michiel Vermeulen +21 more
TL;DR: Oxidized derivatives of mC recruit distinct transcription regulators as well as a large number of DNA repair proteins in mouse ES cells, implicating the DNA damage response as a major player in active DNA demethylation.
Journal ArticleDOI
Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA
Toni Pfaffeneder,Fabio Spada,Mirko Wagner,Caterina Brandmayr,Silvia K. Laube,David Eisen,Matthias Truss,Jessica Steinbacher,Benjamin Hackner,Olga Kotljarova,David Schuermann,Stylianos Michalakis,Olesea Kosmatchev,Stefan Schiesser,Barbara Steigenberger,Nada Raddaoui,Gengo Kashiwazaki,Udo Müller,Cornelia G. Spruijt,Michiel Vermeulen,Heinrich Leonhardt,Primo Schär,Markus Müller,Thomas Carell +23 more
TL;DR: Protein pull-down experiments in combination with peptide tracing identifies hmU as a base that influences binding of chromatin remodeling proteins and transcription factors, suggesting that hm U has a specific function in stem cells besides triggering DNA repair.
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Phosphorylation of TET Proteins Is Regulated via O-GlcNAcylation by the O-Linked N-Acetylglucosamine Transferase (OGT)
Christina Bauer,Klaus Göbel,Nagarjuna Nagaraj,Christian Colantuoni,Mengxi Wang,Udo Müller,Elisabeth Kremmer,Andrea Rottach,Heinrich Leonhardt,Heinrich Leonhardt +9 more
TL;DR: The results provide a novel potential mechanism for TET protein regulation based on a dynamic interplay of phosphorylation and O-GlcNAcylation at the N terminus and the low-complexity insert region.
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TET-mediated oxidation of methylcytosine causes TDG or NEIL glycosylase dependent gene reactivation
TL;DR: Results clearly show that oxidation of methylcytosine by TET dioxygenases and subsequent removal by TDG or NEIL glycosylases and the BER pathway results in reactivation of epigenetically silenced genes.
Journal ArticleDOI
Jumonji domain containing protein 6 (Jmjd6) modulates splicing and specifically interacts with arginine–serine-rich (RS) domains of SR- and SR-like proteins
Astrid Heim,Christina Grimm,Udo Müller,Simon Häußler,Mukram M. Mackeen,Juliane Merl,Stefanie M. Hauck,Benedikt M. Kessler,Christopher J. Schofield,Alexander Wolf,Angelika Böttger +10 more
TL;DR: It is proposed that Jmjd6 exerts its splice modulatory function by interacting with specific SR-related proteins during splicing in a RNA dependent manner.