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Ursula B. Kaiser
Researcher at Brigham and Women's Hospital
Publications - 232
Citations - 16273
Ursula B. Kaiser is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Gonadotropin-releasing hormone & Receptor. The author has an hindex of 62, co-authored 210 publications receiving 14115 citations. Previous affiliations of Ursula B. Kaiser include University of Pennsylvania & St. Michael's Hospital.
Papers
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Journal ArticleDOI
The GPR54 gene as a regulator of puberty
Stephanie B. Seminara,Sophie Messager,Emmanouella E. Chatzidaki,Rosemary R. Thresher,James S. Acierno,Jenna K. Shagoury,Yousef Bo-Abbas,Wendy Kuohung,Kristine M. Schwinof,Alan G. Hendrick,Dirk Zahn,John Dixon,Ursula B. Kaiser,Susan A. Slaugenhaupt,James F. Gusella,Stephen O'Rahilly,Mark Carlton,William F. Crowley,Samuel Aparicio,William H. Colledge +19 more
TL;DR: Puberty is initiated when gonadotropin-releasing hormone begins to be secreted by the hypothalamus, and complementary genetic approaches in humans and mice identified genetic factors that determine the onset of puberty.
Journal ArticleDOI
The GPR54 Gene as a Regulator of Puberty
Stephanie B. Seminara,Sophie Messager,Emmanouella E. Chatzidaki,Rosemary R. Thresher,James S. Acierno,Jenna K. Shagoury,Yousef Bo-Abbas,Wendy Kuohung,Kristine M. Schwinof,Alan G. Hendrick,Dirk Zahn,John Dixon,Ursula B. Kaiser,Susan A. Slaugenhaupt,James F. Gusella,Stephen O'Rahilly,Mark Carlton,William F. Crowley,Samuel Aparicio,William H. Colledge +19 more
TL;DR: Mutations in GPR54, a G protein-coupled receptor gene, cause autosomal recessive idiopathic hypogonadotropic hypogOnadism in humans and mice, suggesting that this receptor is essential for normal gonadotropin-releasing hormone physiology and for puberty.
Journal ArticleDOI
Loss of 5-Hydroxymethylcytosine Is an Epigenetic Hallmark of Melanoma
Christine G. Lian,Yufei Xu,Craig J. Ceol,Craig J. Ceol,Feizhen Wu,Allison R. Larson,Karen Dresser,Wenqi Xu,Li Tan,Yeguang Hu,Qian Zhan,Chung-Wei Lee,Di Hu,Bill Q. Lian,Bill Q. Lian,Sonja Kleffel,Yijun Yang,James Neiswender,Abraham J. Khorasani,Rui Fang,Cecilia Lezcano,Lyn M. Duncan,Richard A. Scolyer,John F. Thompson,Hojabr Kakavand,Yariv Houvras,Yariv Houvras,Leonard I. Zon,Martin C. Mihm,Ursula B. Kaiser,Tobias Schatton,Bruce A. Woda,George F. Murphy,Yujiang Geno Shi,Yujiang Geno Shi +34 more
TL;DR: This study reveals a critical function of 5-hmC in melanoma development and directly links the IDH and TET activity-dependent epigenetic pathway to 5-mC-mediated suppression of melanoma progression, suggesting a new strategy for epigenetic cancer therapy.
Journal ArticleDOI
A GPR54-Activating Mutation in a Patient with Central Precocious Puberty
Milena Gurgel Teles,Suzy D.C. Bianco,Vinicius Nahime Brito,Ericka B. Trarbach,Wendy Kuohung,Wendy Kuohung,Shuyun Xu,Stephanie B. Seminara,Berenice B. Mendonca,Ursula B. Kaiser,Ana Claudia Latronico +10 more
TL;DR: An autosomal dominant GPR54 mutation--the substitution of proline for arginine at codon 386 (Arg386Pro)-- is identified in an adopted girl with idiopathic central precocious puberty (whose biologic family was not available for genetic studies).
Journal ArticleDOI
Central precocious puberty caused by mutations in the imprinted gene MKRN3
Ana Paula Abreu,Andrew Dauber,Delanie B. Macedo,Sekoni D. Noel,Vinicius Nahime Brito,John C. Gill,Priscilla Cukier,Iain R. Thompson,Víctor M. Navarro,Priscila Gagliardi,Tânia Rodrigues,Cristiane Kochi,Carlos Alberto Longui,Dominique Beckers,Francis de Zegher,Luciana Ribeiro Montenegro,Berenice B. Mendonca,Rona S. Carroll,Joel N. Hirschhorn,Ana Claudia Latronico,Ursula B. Kaiser +20 more
TL;DR: Deficiency of MKRN3 causes central precocious puberty in humans, and all affected persons inherited the mutations from their fathers, a finding that indicates perfect segregation with the mode of inheritance expected for an imprinted gene.