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Danielle J. Smyth
Researcher at University of Glasgow
Publications - 48
Citations - 2846
Danielle J. Smyth is an academic researcher from University of Glasgow. The author has contributed to research in topics: Heligmosomoides polygyrus & Immune system. The author has an hindex of 21, co-authored 41 publications receiving 2295 citations. Previous affiliations of Danielle J. Smyth include University of Queensland & Commonwealth Scientific and Industrial Research Organisation.
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Journal ArticleDOI
Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites
François Gerbe,François Gerbe,François Gerbe,Emmanuelle Sidot,Emmanuelle Sidot,Emmanuelle Sidot,Danielle J. Smyth,Makoto Ohmoto,Ichiro Matsumoto,Valerie Dardalhon,Valerie Dardalhon,Pierre Cesses,Pierre Cesses,Pierre Cesses,Laure Garnier,Laure Garnier,Laure Garnier,Marie Pouzolles,Marie Pouzolles,Bénédicte Brulin,Bénédicte Brulin,Bénédicte Brulin,Marco Bruschi,Marco Bruschi,Marco Bruschi,Yvonne Harcus,Valérie S. Zimmermann,Valérie S. Zimmermann,Naomi Taylor,Naomi Taylor,Rick M. Maizels,Philippe Jay,Philippe Jay,Philippe Jay +33 more
TL;DR: It is shown that tuft cells, a rare epithelial cell type in the steady-state intestinal epithelium, are responsible for initiating type 2 responses to parasites by a cytokine-mediated cellular relay and a cellular relay required for initiating mucosal type 2 immunity to helminth infection.
Journal ArticleDOI
Tetraspanins on the surface of Schistosoma mansoni are protective antigens against schistosomiasis
Mai H. Tran,Mark S. Pearson,Jeffrey M. Bethony,Jeffrey M. Bethony,Danielle J. Smyth,Malcolm K. Jones,Mary Duke,Tegan A. Don,Donald P. McManus,Rodrigo Correa-Oliveira,Alex Loukas +10 more
TL;DR: TSP-2 in particular provided protection in excess of the 40% benchmark set by the World Health Organization for progression of schistosome vaccine antigens into clinical trials, and seems to be an effective vaccine antigen against S. mansoni.
Journal ArticleDOI
Proteomics Analysis of the Excretory/Secretory Component of the Blood-feeding Stage of the Hookworm, Ancylostoma caninum
Jason Mulvenna,Brett Hamilton,Shivashankar H. Nagaraj,Danielle J. Smyth,Alex Loukas,Jeffrey J. Gorman +5 more
TL;DR: This work identified a suite of proteins important for the parasitic lifestyle and provides new insight into the biology of hookworm infection.
Journal ArticleDOI
Prostaglandin E2 constrains systemic inflammation through an innate lymphoid cell-IL-22 axis
Rodger Duffin,Richard A. O’Connor,Siobhan Crittenden,Thorsten Forster,Cunjing Yu,Xiaozhong Zheng,Danielle J. Smyth,Calum T. Robb,Fiona Rossi,Christos Skouras,Shaohui Tang,James Richards,Antonella Pellicoro,Richard Weller,Richard M. Breyer,Damian J. Mole,John P. Iredale,Stephen M. Anderton,Shuh Narumiya,Rick M. Maizels,Peter Ghazal,Sarah E. M. Howie,Adriano G. Rossi,Chengcan Yao +23 more
TL;DR: A role for prostaglandin E2 in keeping systemic inflammation in check is reported on, and it is demonstrated that PGE2-EP4 signaling acts directly on type 3 innate lymphoid cells (ILCs), promoting their homeostasis and driving them to produce interleukin-22 (IL-22).
Journal ArticleDOI
A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells
Chris J. C. Johnston,Danielle J. Smyth,Danielle J. Smyth,Ravindra Kodali,Madeleine P. J. White,Yvonne Harcus,Kara J. Filbey,Kara J. Filbey,James P. Hewitson,James P. Hewitson,Cynthia S. Hinck,Alasdair Ivens,Andrea M. Kemter,Anna Overgaard Kildemoes,Anna Overgaard Kildemoes,Thierry Le Bihan,Dinesh C. Soares,Stephen M. Anderton,Thomas Brenn,Stephen J. Wigmore,Hannah V. Woodcock,Rachel C. Chambers,Andrew P. Hinck,Henry J. McSorley,Rick M. Maizels +24 more
TL;DR: The data indicate that through convergent evolution, the mouse parasite has acquired a protein with cytokine-like function that is able to exploit an endogenous pathway of immunoregulation in the host.