E
Edward T. Ryan
Researcher at Harvard University
Publications - 335
Citations - 15151
Edward T. Ryan is an academic researcher from Harvard University. The author has contributed to research in topics: Vibrio cholerae & Cholera. The author has an hindex of 60, co-authored 303 publications receiving 11822 citations. Previous affiliations of Edward T. Ryan include Charles Stark Draper Laboratory & University of Colorado Colorado Springs.
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Journal ArticleDOI
SARS-CoV-2 viral load is associated with increased disease severity and mortality.
Jesse Fajnzylber,James Regan,Kendyll Coxen,Heather Corry,Colline Wong,Alexandra Rosenthal,Daniel P Worrall,Francoise Giguel,Alicja Piechocka-Trocha,Caroline Atyeo,Stephanie Fischinger,Andrew T. Chan,Keith T. Flaherty,Kathryn T. Hall,Michael Dougan,Edward T. Ryan,Elizabeth Gillespie,Rida Chishti,Yijia Li,Nikolaus Jilg,Nikolaus Jilg,Dusan Hanidziar,Rebecca M. Baron,Lindsey R. Baden,Athe M. N. Tsibris,Katrina Armstrong,Daniel R. Kuritzkes,Galit Alter,Galit Alter,Bruce D. Walker,Bruce D. Walker,Bruce D. Walker,Xu G. Yu,Xu G. Yu,Jonathan Z. Li +34 more
TL;DR: It is reported that a higher prevalence of detectable SARS-CoV-2 plasma viral load is associated with worse respiratory disease severity, lower absolute lymphocyte counts, and increased markers of inflammation, including C-reactive protein and IL-6.
Journal ArticleDOI
Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients.
Anita S. Iyer,Forrest K. Jones,Ariana Nodoushani,Meagan Kelly,Margaret Becker,Damien Slater,Rachel Mills,Erica Teng,Mohammad Kamruzzaman,Wilfredo F. Garcia-Beltran,Michael G Astudillo,Diane Yang,Tyler E. Miller,Elizabeth Oliver,Stephanie Fischinger,Caroline Atyeo,A. John Iafrate,Stephen B. Calderwood,Stephen A. Lauer,Jingyou Yu,Zhenfeng Li,Jared Feldman,Blake M. Hauser,Timothy M. Caradonna,John A. Branda,Sarah E Turbett,Regina C. LaRocque,Guillaume Mellon,Dan H. Barouch,Dan H. Barouch,Aaron G. Schmidt,Aaron G. Schmidt,Andrew S. Azman,Galit Alter,Edward T. Ryan,Jason B. Harris,Richelle C. Charles +36 more
TL;DR: RBD-targeted antibodies are excellent markers of previous and recent infection, that differential isotype measurements can help distinguish between recent and older infections, and that IgG responses persist over the first few months after infection and are highly correlated with neutralizing antibodies.
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Morbidity and mortality due to shigella and enterotoxigenic Escherichia coli diarrhoea: the Global Burden of Disease Study 1990-2016.
Ibrahim A Khalil,Christopher Troeger,Brigette F. Blacker,Puja C Rao,Alexandria Brown,Deborah Atherly,Thomas G Brewer,Cyril Engmann,Cyril Engmann,Eric R. Houpt,Gagandeep Kang,Karen L. Kotloff,Myron M. Levine,Stephen P. Luby,Calman A. MacLennan,William Pan,William Pan,Patricia B Pavlinac,James A Platts-Mills,Firdausi Qadri,Mark S. Riddle,Edward T. Ryan,David A Shoultz,A. Duncan Steele,Judd L. Walson,John W. Sanders,Ali H. Mokdad,Christopher J L Murray,Simon I. Hay,Simon I. Hay,Robert Reiner +30 more
TL;DR: The global burden of shigella and ETEC diarrhoea according to age, sex, geography, and year from 1990 to 2016 is analyzed to assess the health burden of bacterial diarrhoeal pathogens globally.
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Primaquine: report from cdc expert meeting on malaria chemoprophylaxis i
TL;DR: There are three uses for primaquine in malaria: radical cure of established infection with P. vivax or P. ovale malaria; presumptive anti-relapse therapy (PART) in persons with extensive exposure to these parasites; and primary prophylaxis against all malaria species.
Journal ArticleDOI
Distinct Early Serological Signatures Track with SARS-CoV-2 Survival.
Caroline Atyeo,Caroline Atyeo,Stephanie Fischinger,Stephanie Fischinger,Tomer Zohar,Tomer Zohar,Matthew D. Slein,John F. Burke,Carolin Loos,Carolin Loos,Denise J. McCulloch,Kira L. Newman,Caitlin R Wolf,Jingyou Yu,Kiel Shuey,Jared Feldman,Blake M. Hauser,Timothy M. Caradonna,Aaron G. Schmidt,Todd J. Suscovich,Caitlyn Linde,Yongfei Cai,Dan H. Barouch,Edward T. Ryan,Richelle C. Charles,Douglas A. Lauffenburger,Helen Y. Chu,Galit Alter +27 more
TL;DR: It is demonstrated that early antigen-specific and qualitative features of SARS-CoV-2-specific antibodies, point to differences in disease trajectory, highlighting the potential importance of functional antigen- specific humoral immunity to guide patient care and vaccine development.