V
Vicente Felipo
Researcher at Spanish National Research Council
Publications - 357
Citations - 13974
Vicente Felipo is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Hyperammonemia & Glutamate receptor. The author has an hindex of 60, co-authored 335 publications receiving 12520 citations. Previous affiliations of Vicente Felipo include Universidad Miguel Hernández de Elche & University of Seville.
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Inflammation and hepatic encephalopathy: ibuprofen restores learning ability in rats with portacaval shunts.
TL;DR: Ibuprofen normalizes the function of the glutamate‐NO‐cGMP pathway in cerebral cortex in brain in vivo and completely restores the ability of rats with chronic liver failure to learn the Y‐maze task, which supports that inflammation contributes to the cognitive impairment in hepatic encephalopathy.
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Chronic hyperammonemia impairs the glutamate-nitric oxide-cyclic GMP pathway in cerebellar neurons in culture and in the rat in vivo.
Carlos Hermenegildo,Carmina Montoliu,Marta Llansola,María-Dolores Muñoz,José-María Gaztelu,María-Dolores Miñana,Vicente Felipo +6 more
TL;DR: Long‐term treatment of cultured neurons with ammonia prevents glutamate‐induced neuronal death and the induction of the protective effect was not immediate, but took several hours.
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Oral administration of sildenafil restores learning ability in rats with hyperammonemia and with portacaval shunts
Slaven Erceg,Pilar Monfort,Mariluz Hernández-Viadel,Regina Rodrigo,Carmina Montoliu,Vicente Felipo +5 more
TL;DR: Impaired learning ability in rats with chronic liver failure or with hyperammonemia is the result of impairment of the glutamate‐NO‐cGMP pathway, and chronic treatment with sildenafil normalizes the function of the pathway and restores learning ability.
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Contribution of hyperammonemia and inflammatory factors to cognitive impairment in minimal hepatic encephalopathy.
Vicente Felipo,Amparo Urios,Encarna Montesinos,Inmaculada Molina,M. L. Garcia-Torres,Miguel Civera,Juan A. del Olmo,Joaquín Ortega,Jose Martinez-Valls,Miguel A. Serra,Norberto Cassinello,A. Wassel,Esperanza Jordá,Carmina Montoliu +13 more
TL;DR: The data reported show that in patients with liver diseases, cognitive impairment may appear before progression to cirrhosis if hyperammonemia and inflammation are high enough, even without liver disease.
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Blocking NMDA receptors prevents the oxidative stress induced by acute ammonia intoxication
TL;DR: It is shown that MK-801, an antagonist of NMDA receptors prevents ammonia-induced changes in superoxide dismutase, glutathione peroxidase and catalase, suggesting that oxidative stress can play a role in the mechanism of ammonia toxicity.