V
Vicente Felipo
Researcher at Spanish National Research Council
Publications - 357
Citations - 13974
Vicente Felipo is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Hyperammonemia & Glutamate receptor. The author has an hindex of 60, co-authored 335 publications receiving 12520 citations. Previous affiliations of Vicente Felipo include Universidad Miguel Hernández de Elche & University of Seville.
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Journal ArticleDOI
Chronic hyperammonemia induces peripheral inflammation that leads to cognitive impairment in rats: Reversed by anti-TNF-α treatment.
Tiziano Balzano,Sherry Dadsetan,Jerónimo Forteza,Andrea Cabrera-Pastor,Lucas Taoro-Gonzalez,Michele Malaguarnera,Sara Gil-Perotin,Laura Cubas-Nuñez,Bonaventura Casanova,Agueda Castro-Quintas,Alejandro Ponce-Mora,Yaiza M. Arenas,Paola E. Leone,Slaven Erceg,Marta Llansola,Vicente Felipo +15 more
TL;DR: It is shown that reducing peripheral inflammation by treating rats with anti-TNFa, which does not cross the blood-brain barrier, prevents hyperammonemia-induced neuroinflammation, alterations in neurotransmission and cognitive impairment.
Journal ArticleDOI
Reducing Peripheral Inflammation with Infliximab Reduces Neuroinflammation and Improves Cognition in Rats with Hepatic Encephalopathy.
Sherry Dadsetan,Tiziano Balzano,Jerónimo Forteza,Andrea Cabrera-Pastor,Lucas Taoro-Gonzalez,Vicente Hernandez-Rabaza,Sara Gil-Perotin,Laura Cubas-Nuñez,José Manuel García-Verdugo,Ana Agusti,Marta Llansola,Vicente Felipo +11 more
TL;DR: Treatment with anti-TNF-a could be a new therapeutic approach to improve cognitive function in patients with HE and suggest that peripheral inflammation contributes to spatial learning impairment in PCS rats.
Journal ArticleDOI
Neuroinflammation contributes to hypokinesia in rats with hepatic encephalopathy: ibuprofen restores its motor activity.
Omar Cauli,Regina Rodrigo,Blanca Piedrafita,Marta Llansola,Mohammad Taghi Mansouri,Vicente Felipo +5 more
TL;DR: Assessment of whether treatment with an antiinflammatory, ibuprofen, is able to normalize extracellular glutamate in SNr and/or to improve hypokinesia in PCS rats supports the idea that inflammation is a main contributor to the induction of hypokitesia in hepatic encephalopathy and points to the possible therapeutic utility of decreasing inflammation, by safe procedures, in the treatment of the motor deficits in patients with hepaticEncephalopathy.
Journal ArticleDOI
Aluminium impairs the glutamate-nitric oxide-cGMP pathway in cultured neurons and in rat brain in vivo: molecular mechanisms and implications for neuropathology.
Juan J. Canales,Regina Corbalán,Carmina Montoliu,Marta Llansola,Pilar Monfort,Slaven Erceg,Mariluz Hernández-Viadel,Vicente Felipo +7 more
TL;DR: The impairment of the Glu-NO-cGMP pathway in the brain may be responsible for some of the neurological alterations induced by Al, as assessed by in vivo brain microdialysis in freely moving rats.
Journal ArticleDOI
3-nitro-tyrosine as a peripheral biomarker of minimal hepatic encephalopathy in patients with liver cirrhosis.
Carmina Montoliu,Omar Cauli,Amparo Urios,Nisrin ElMlili,Miguel A. Serra,Remedios Giner-Durán,Olga González-Lopez,Juan A. del Olmo,A. Wassel,José M. Rodrigo,Vicente Felipo +10 more
TL;DR: In this paper, Nitro-Tyrosine as a peripheral biomarker of minimal hepatic encephalopathy in patients with Liver cirrhosis was used. But they did not identify any patients with liver cancer.