V
Vicente Felipo
Researcher at Spanish National Research Council
Publications - 357
Citations - 13974
Vicente Felipo is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Hyperammonemia & Glutamate receptor. The author has an hindex of 60, co-authored 335 publications receiving 12520 citations. Previous affiliations of Vicente Felipo include Universidad Miguel Hernández de Elche & University of Seville.
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Journal ArticleDOI
Polychlorinated biphenyls PCB 52, PCB 180, and PCB 138 impair the glutamate-nitric oxide-cGMP pathway in cerebellar neurons in culture by different mechanisms.
TL;DR: Results show that chronic exposure to nondioxin-like PCB52, PCB138, or PCB180 impairs the function of the glutamate-NO-cGMP pathway in cerebellar neurons by different mechanisms and with different potencies.
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Modulation of Glutamine Synthesis in Cultured Astrocytes by Nitric Oxide
María-Dolores Miñana,Elena Kosenko,Goizane Marcaida,Carlos Hermenegildo,Carmina Montoliu,Santiago Grisolia,Vicente Felipo +6 more
TL;DR: It is shown that S-nitroso-N-acetylpenicillamine decreases glutamine synthesis in intact astrocytes by ≈40–50%.
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Cyclic GMP pathways in hepatic encephalopathy. Neurological and therapeutic implications.
Carmina Montoliu,Regina Rodrigo,Pilar Monfort,Marta Llansola,Omar Cauli,Jordi Boix,Nisrin ElMlili,Ana Agusti,Vicente Felipo +8 more
TL;DR: Data support that increasing cGMP by safe pharmacological means may be a new therapeutic approach to improve cognitive function in patients with minimal or clinical HE.
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Focal cortical damage parallels cognitive impairment in minimal hepatic encephalopathy.
Carmina Montoliu,Gabriel Gonzalez-Escamilla,Mercedes Atienza,Amparo Urios,O. Gonzalez,A. Wassel,Roberto Aliaga,Remedios Giner-Durán,Miguel A. Serra,José M. Rodrigo,Vicente Belloch,Vicente Felipo,Jose L. Cantero +12 more
TL;DR: Findings provide the first report of cortical thinning in MHE patients, and they yield novel insights into the neurobiological basis of cognitive impairment associated with early stages of liver diseases.
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Increasing the function of the glutamate-nitric oxide-cyclic guanosine monophosphate pathway increases the ability to learn a Y-maze task
TL;DR: The results show that the function of the glutamate‐NO‐cGMP modulates the ability of rats to learn the Y‐maze task, that thefunction of the pathway under physiological conditions is not optimal for learning, and that performance in the Y-mazetask may be improved by enhancing slightly the functionof the pathway and cGMP formation.