V
Vikas Saxena
Researcher at University of Maryland, Baltimore
Publications - 42
Citations - 534
Vikas Saxena is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Medicine & Immune system. The author has an hindex of 10, co-authored 23 publications receiving 311 citations. Previous affiliations of Vikas Saxena include Academia Sinica & Ohio State University.
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Journal ArticleDOI
Annexin A2 is involved in the formation of hepatitis C virus replication complex on the lipid raft
TL;DR: It is proposed that Anxa2 recruits HCV NS proteins and enriches them on the lipid raft to form the HCV replication complex.
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Affinity chromatography: A versatile technique for antibody purification.
TL;DR: A detailed overview on affinity chromatography and the components involved in purification is provided to provide a detailed overview of antibody purification methodologies and their underlying working principles.
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Gut microbiota–dependent modulation of innate immunity and lymph node remodeling affects cardiac allograft outcomes
Jonathan S. Bromberg,Lauren E. Hittle,Yanbao Xiong,Vikas Saxena,Eoghan M. Smyth,Lushen Li,Tianshu Zhang,Chelsea Wagner,W. Florian Fricke,Thomas Simon,C. Colin Brinkman,Emmanuel F. Mongodin +11 more
TL;DR: Analysis of mesenteric and peripheral lymph node structure showed that B. pseudolongum gavage resulted in a higher laminin α4/α5 ratio in the lymph node cortical ridge, indicative of a suppressive environment, while D. desulfuricans results in a lower lamination ratio, supportive of inflammation.
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NFκB-Pim-1-Eomesodermin axis is critical for maintaining CD8 T-cell memory quality.
Karin M. Knudson,Karin M. Knudson,Curtis J. Pritzl,Vikas Saxena,Amnon Altman,Mark A. Daniels,Emma Teixeiro +6 more
TL;DR: It is shown that in T cells transitioning to memory, the expression of high levels of Eomes is not constitutive but rather requires a continuum of cell-intrinsic NFκB signaling, which regulates Eomes levels to maintain memory fitness.
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Role of lymph node stroma and microenvironment in T cell tolerance
Vikas Saxena,Lushen Li,Christina Paluskievicz,Vivek Kasinath,Asher Bean,Reza Abdi,Christopher M. Jewell,Christopher M. Jewell,Jonathan S. Bromberg +8 more
TL;DR: Increased understanding of LN architecture, how different LN SCs integrate immunological cues and shape immune responses, and approaches to induce T cell tolerance will help further combat autoimmune diseases and graft rejection.