V
Viviana Gradinaru
Researcher at California Institute of Technology
Publications - 160
Citations - 21884
Viviana Gradinaru is an academic researcher from California Institute of Technology. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 49, co-authored 137 publications receiving 16560 citations. Previous affiliations of Viviana Gradinaru include Laboratory of Molecular Biology & Howard Hughes Medical Institute.
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Journal ArticleDOI
Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
Timothy R. Sampson,Justine W. Debelius,Taren Thron,Stefan Janssen,Gauri G. Shastri,Zehra Esra Ilhan,Collin Challis,Catherine E. Schretter,Sandra Rocha,Viviana Gradinaru,Marie-Françoise Chesselet,Ali Keshavarzian,Kathleen M. Shannon,Rosa Krajmalnik-Brown,Pernilla Wittung-Stafshede,Rob Knight,Sarkis K. Mazmanian +16 more
TL;DR: It is reported herein that gut microbiota are required for motor deficits, microglia activation, and αSyn pathology, and suggested that alterations in the human microbiome represent a risk factor for PD.
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Structural and molecular interrogation of intact biological systems
Kwanghun Chung,Jenelle Wallace,Sung-Yon Kim,Sandhiya Kalyanasundaram,Aaron S. Andalman,Thomas J. Davidson,Julie J. Mirzabekov,Kelly A. Zalocusky,Joanna Mattis,Aleksandra K. Denisin,Sally Pak,Hannah L. Bernstein,Charu Ramakrishnan,Logan Grosenick,Viviana Gradinaru,Karl Deisseroth +15 more
TL;DR: It is shown that CLARITY enables fine structural analysis of clinical samples, including non-sectioned human tissue from a neuropsychiatric-disease setting, establishing a path for the transmutation of human tissue into a stable, intact and accessible form suitable for probing structural and molecular underpinnings of physiological function and disease.
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Optical Deconstruction of Parkinsonian Neural Circuitry
TL;DR: This work used optogenetics and solid-state optics to systematically drive or inhibit an array of distinct circuit elements in freely moving parkinsonian rodents and found that therapeutic effects within the subthalamic nucleus can be accounted for by direct selective stimulation of afferent axons projecting to this region.
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Amygdala circuitry mediating reversible and bidirectional control of anxiety
Kay M. Tye,Rohit Prakash,Sung-Yon Kim,Lief E. Fenno,Logan Grosenick,Hosniya Zarabi,Kimberly R. Thompson,Viviana Gradinaru,Charu Ramakrishnan,Karl Deisseroth +9 more
TL;DR: The results implicate specific BLA–CeA projections as critical circuit elements for acute anxiety control in the mammalian brain, and demonstrate the importance of optogenetically targeting defined projections, beyond simply targeting cell types, in the study of circuit function relevant to neuropsychiatric disease.
Journal ArticleDOI
Molecular and Cellular Approaches for Diversifying and Extending Optogenetics
Viviana Gradinaru,Feng Zhang,Charu Ramakrishnan,Joanna Mattis,Rohit Prakash,Ilka Diester,Inbal Goshen,Kimberly R. Thompson,Karl Deisseroth,Karl Deisseroth +9 more
TL;DR: Subcellular and transcellular trafficking strategies now permit increased potency of optical inhibition without increased light power requirement, and generalizable strategies for targeting cells based not only on genetic identity, but also on morphology and tissue topology, to allow versatile targeting when promoters are not known or in genetically intractable organisms.