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Wenting Guo
Researcher at Katholieke Universiteit Leuven
Publications - 30
Citations - 1012
Wenting Guo is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Neurodegeneration & Medicine. The author has an hindex of 11, co-authored 18 publications receiving 597 citations. Previous affiliations of Wenting Guo include Shanghai Jiao Tong University & Allen Institute for Brain Science.
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Journal ArticleDOI
HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients
Wenting Guo,Maximilian Naujock,Maximilian Naujock,Laura Fumagalli,Tijs Vandoorne,Pieter Baatsen,Ruben Boon,Laura Ordovás,Laura Ordovás,Abdulsamie Patel,Marc Welters,Thomas Vanwelden,Natasja Geens,Tine Tricot,Veronick Benoy,Jolien Steyaert,Cynthia Lefebvre-Omar,Werend Boesmans,Matthew Jarpe,Jared Sterneckert,Florian Wegner,Susanne Petri,Delphine Bohl,Pieter Vanden Berghe,Wim Robberecht,Philip Van Damme,Catherine M. Verfaillie,Ludo Van Den Bosch +27 more
TL;DR: Using motor neurons derived from induced pluripotent stem cells from patients with ALS and FUS mutations, the authors demonstrate that axonal transport deficits that are observed in these cells can be rescued by HDAC6 inhibition.
Journal ArticleDOI
Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis
Haibo Wang,Wenting Guo,Wenting Guo,Joy Mitra,Pavana M. Hegde,Tijs Vandoorne,Tijs Vandoorne,Bradley J. Eckelmann,Bradley J. Eckelmann,Sankar Mitra,Sankar Mitra,Alan E. Tomkinson,Ludo Van Den Bosch,Ludo Van Den Bosch,Muralidhar L. Hegde,Muralidhar L. Hegde +15 more
TL;DR: The authors investigate the mechanisms of defects in repair caused by mutations in the RNA/DNA binding protein FUS in amyotrophic lateral sclerosis and elucidate its role in the DNA ligation during DNA single-strand break repair of oxidative breaks.
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Efficient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition
Laura Ordovás,Ruben Boon,Mariaelena Pistoni,Yemiao Chen,Esther Wolfs,Wenting Guo,Rangarajan Sambathkumar,Sylwia Bobis-Wozowicz,Nicky Helsen,Jolien Vanhove,Pieter Berckmans,Qing Cai,Kim Vanuytsel,Kristel Eggermont,Veerle Vanslembrouck,Béla Z. Schmidt,Béla Z. Schmidt,Susanna Raitano,Ludo Van Den Bosch,Yaakov Nahmias,Toni Cathomen,Tom Struys,Catherine M. Verfaillie +22 more
TL;DR: The AAVS1 locus cannot be considered a universally safe harbor locus for reliable transgene expression in vitro, and using it for transgenesis in hPSC will require careful assessment of the function of individual transgenes.
Journal ArticleDOI
Axonal transport defects and neurodegeneration: Molecular mechanisms and therapeutic implications
TL;DR: The discovery of mutations in human genes involved in the transport machinery provide a direct causative relationship between axonal transport defects and neurodegeneration.
Journal ArticleDOI
A nonsense mutation in DHTKD1 causes Charcot-Marie-Tooth disease type 2 in a large Chinese pedigree.
Wang-Yang Xu,Ming-min Gu,Lian-hua Sun,Wenting Guo,Houbao Zhu,Jian-Fang Ma,Wentao Yuan,Ying Kuang,Bao-jun Ji,Xiao-lin Wu,Yan Chen,Hong-Xin Zhang,Fu-ting Sun,Wei Huang,Lei Huang,Sheng-Di Chen,Zhugang Wang +16 more
TL;DR: The data demonstrate that the heterozygous nonsense mutation in DHTKD1 is one of CMT2-causative genetic alterations, implicating an important role for DHTkD1 in mitochondrial energy production and neurological development.