R
Ruben Boon
Researcher at Katholieke Universiteit Leuven
Publications - 30
Citations - 1929
Ruben Boon is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Induced pluripotent stem cell & Cellular differentiation. The author has an hindex of 15, co-authored 27 publications receiving 1200 citations. Previous affiliations of Ruben Boon include Broad Institute & Harvard University.
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Journal ArticleDOI
Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity
Kim Vriens,Stefan Christen,Sweta Parik,Dorien Broekaert,Kazuaki Yoshinaga,Ali Talebi,Jonas Dehairs,Carmen Escalona-Noguero,Roberta Schmieder,Thomas Cornfield,Catriona Charlton,Laura Romero-Pérez,Matteo Rossi,Gianmarco Rinaldi,Martin F. Orth,Ruben Boon,Axelle Kerstens,Suet Ying Kwan,Brandon Faubert,Andrés Méndez-Lucas,Charlotte Kopitz,Ting Chen,Juan Fernández-García,Joao A.G. Duarte,Arndt Schmitz,Patrick Steigemann,Mustapha Najimi,Andrea Hägebarth,Jo A. Van Ginderachter,Etienne Sokal,Naohiro Gotoh,Kwok-Kin Wong,Catherine M. Verfaillie,Rita Derua,Sebastian Munck,Mariia Yuneva,Laura Beretta,Ralph J. DeBerardinis,Johannes V. Swinnen,Leanne Hodson,David Cassiman,Chris Verslype,Sven Christian,Sylvia Grünewald,Thomas G. P. Grunewald,Sarah-Maria Fendt +45 more
TL;DR: In several human and mouse cancer cell lines and carcinomas, a sapienate biosynthesis pathway underpins metabolic plasticity by allowing these cells to bypass stearoyl-CoA desaturase-dependent fatty acid desaturation.
Journal ArticleDOI
Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells
Ilaria Elia,Dorien Broekaert,Stefan Christen,Ruben Boon,Enrico Radaelli,Martin F. Orth,Catherine M. Verfaillie,Thomas G. P. Grunewald,Sarah-Maria Fendt +8 more
TL;DR: It is discovered that proline catabolism via proline dehydrogenase (Prodh) supports growth of breast cancer cells in 3D culture and is a potential drug target for inhibiting metastasis formation.
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HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients
Wenting Guo,Maximilian Naujock,Maximilian Naujock,Laura Fumagalli,Tijs Vandoorne,Pieter Baatsen,Ruben Boon,Laura Ordovás,Laura Ordovás,Abdulsamie Patel,Marc Welters,Thomas Vanwelden,Natasja Geens,Tine Tricot,Veronick Benoy,Jolien Steyaert,Cynthia Lefebvre-Omar,Werend Boesmans,Matthew Jarpe,Jared Sterneckert,Florian Wegner,Susanne Petri,Delphine Bohl,Pieter Vanden Berghe,Wim Robberecht,Philip Van Damme,Catherine M. Verfaillie,Ludo Van Den Bosch +27 more
TL;DR: Using motor neurons derived from induced pluripotent stem cells from patients with ALS and FUS mutations, the authors demonstrate that axonal transport deficits that are observed in these cells can be rescued by HDAC6 inhibition.
Journal ArticleDOI
Breast cancer cells rely on environmental pyruvate to shape the metastatic niche
Ilaria Elia,Matteo Rossi,Steve Stegen,Dorien Broekaert,Ginevra Doglioni,Marit van Gorsel,Ruben Boon,Carmen Escalona-Noguero,Sophie Torrekens,Catherine M. Verfaillie,Erik Verbeken,Geert Carmeliet,Sarah-Maria Fendt +12 more
TL;DR: It is shown that breast cancer cells rely on the nutrient pyruvate to drive collagen-based remodelling of the extracellular matrix in the lung metastatic niche, and a mechanistic understanding of the link between collagen remodelling and the nutrient environment in the metastasis niche is provided.
Journal ArticleDOI
Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis
Mar Coll,L. Perea,Ruben Boon,Sofia B. Leite,Julia Vallverdú,Inge Mannaerts,Ayla Smout,Adil El Taghdouini,Delia Blaya,Daniel Rodrigo-Torres,Isabel Graupera,Beatriz Aguilar-Bravo,Christophe Chesne,Mustapha Najimi,Etienne Sokal,Juan José Lozano,Leo A. van Grunsven,Catherine M. Verfaillie,Pau Sancho-Bru +18 more
TL;DR: Efficient differentiation of human pluripotent stem cells into HSC-like cells (iPSC-HSCs) is reported, which provides a robust in-vitro system for studying HSC development, modeling liver fibrosis, and drug toxicity screening.