Tine Tricot

TL;DR: Using motor neurons derived from induced pluripotent stem cells from patients with ALS and FUS mutations, the authors demonstrate that axonal transport deficits that are observed in these cells can be rescued by HDAC6 inhibition.

TL;DR: It is demonstrated that increasing extracellular amino acids beyond the nutritional need of HLCs and HepG2 cells induces glucose independence, mitochondrial function, and the acquisition of a transcriptional profile that is closer to PHHs.

TL;DR: This study uses RNA-Seq to analyze the following human in vitro liver cell models in comparison to human liver tissue and finds that 3D liver microtissues exhibited a high similarity with in vivo liver, while HepG2 cells illustrated the lowest similarity.

TL;DR: The underlying mechanisms for severe acute respiratory syndrome coronavirus (SARS-CoV-2) pathogenesis are reviewed and available therapeutic candidates and advanced modalities that are being currently evaluated in in vitro/in vivo models and of note in clinical trials are discussed.

TL;DR: Modification of the chemical microenvironment, as well as the use of bioengineering tools to recreate the cellular, extracellular matrix, and physical characteristics of the niche wherein progenitors and mature cells reside, is now being used to further improve the maturation and functionality of stem cell progeny.