Thomas Vanwelden

TL;DR: Using motor neurons derived from induced pluripotent stem cells from patients with ALS and FUS mutations, the authors demonstrate that axonal transport deficits that are observed in these cells can be rescued by HDAC6 inhibition.

TL;DR: It is demonstrated that increasing extracellular amino acids beyond the nutritional need of HLCs and HepG2 cells induces glucose independence, mitochondrial function, and the acquisition of a transcriptional profile that is closer to PHHs.

TL;DR: It is reported that FL HSCs use oxygen dependent energy generating pathways significantly more than their BM counterparts, and that higher levels of DNA repair and antioxidant pathway gene expression may prevent ROS-mediated (geno)toxicity in FL H SCs.

TL;DR: It is shown that Prdm12 expression is restricted to developing and adult nociceptors and that its genetic ablation compromises their viability and maturation.

TL;DR: In this paper, RNA sequencing-based gene expression analysis on 14.5-day mouse embryo (E14.5) was performed to identify key transcriptional regulators that play important roles in the expansion of HSCs during development.