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William G. Nelson
Researcher at Johns Hopkins University School of Medicine
Publications - 302
Citations - 32149
William G. Nelson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Prostate cancer & Prostate. The author has an hindex of 93, co-authored 292 publications receiving 30356 citations. Previous affiliations of William G. Nelson include New York University & Johns Hopkins University.
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Journal ArticleDOI
Inflammation in prostate carcinogenesis
Angelo M. De Marzo,Angelo M. De Marzo,Elizabeth A. Platz,Siobhan Sutcliffe,Jianfeng Xu,Henrik Grönberg,Charles G. Drake,Yasutomo Nakai,William B. Isaacs,William G. Nelson +9 more
TL;DR: Whether prostate cancer is driven by inflammation, and if so, to develop new strategies to prevent the disease, is determined by developing new experimental animal models coupled with classical Epidemiological studies, genetic epidemiological studies and molecular pathological approaches.
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Proliferative Inflammatory Atrophy of the Prostate : Implications for Prostatic Carcinogenesis
TL;DR: De Marzo et al. as discussed by the authors used immunohistochemistry to characterize the phenotype of the atrophic cells to assess the feasibility of the proposal that they may be targets of neoplastic transformation.
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Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis
Wen-Hsiang Lee,Ronald A. Morton,Jonathan I. Epstein,James D. Brooks,Pearl A. Campbell,G S Bova,Wen Son Hsieh,William B. Isaacs,William G. Nelson +8 more
TL;DR: Methylation of cytidine nucleotides in GSTP1 regulatory sequences constitutes the most common genomic alteration yet described for human prostate cancer.
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DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.
TL;DR: It is concluded that DNA strand breaks were sufficient for initiating p53-dependent signal transduction after finding that introduction of nucleases into cells by electroporation stimulated rapid p53 protein elevations.
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Immunolocalization of keratin polypeptides in human epidermis using monoclonal antibodies.
TL;DR: Three monoclonal antibodies (AE1, AE2, and AE3) were prepared against human epidermal keratins and used to study keratin expression during normalEpidermal differentiation, showing that certain keratin antigens must be masked in situ by direct analysis of ker atins extracted from serial, horizontal skin sections using the immunoblot technique.