Wy Ching Ng

TL;DR: The highly structured 3′UTR is responsible for the generation of subgenomic flavivirus RNA (sfRNA) that helps the virus evade host immune response, thereby affecting viral pathogenesis and the development of vaccines.

TL;DR: Detailed analyses of viral RNA structure in virions and in infected cells for four dengue virus serotypes and four Zika virus strains are provided, and conserved structures that are important for virus replication are identified.

TL;DR: A ZIKV variant that produces small plaques due to interferon (IFN)-restricted viral propagation and displays attenuated infection of endothelial cells is identified and it is shown that these properties collectively reduce the risk of organ infections and vertical transmission in a mouse model but remain sufficiently immunogenic to prevent wild-type ZikV infection.

TL;DR: A novel function of QKI is described in restricting viral replication by mapping the QKI interaction site and identifying a QKI response element in DENV4 3' UTR.

TL;DR: The site-directed mutagenesis on a 16681 infectious clone identifies a single G53D substitution in the non-structural 1 (NS1) protein that reduces 16681 infection and dissemination in both Aedes aegypti, as well as in mammalian cells to produce the characteristic phenotypes of PDK53.