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Xihong Lin
Researcher at Harvard University
Publications - 389
Citations - 32083
Xihong Lin is an academic researcher from Harvard University. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 76, co-authored 361 publications receiving 26162 citations. Previous affiliations of Xihong Lin include Texas A&M University & University of Washington.
Papers
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Posted ContentDOI
Connectivity of variants in eQTL networks dictates reproducibility and functionality
TL;DR: The network metric of degree is defined to be estimated by false discovery rates, test statistics, and p-values of the eQTL regressions in order to represent how central and potentially influential a SNP is to the network.
Journal ArticleDOI
Discussion of “Evaluate the Risk of Resumption of Business for the States of New York, New Jersey and Connecticut via a Pre-Symptomatic and Asymptomatic Transmission Model of COVID-19”
Corbin Quick,Xihong Lin +1 more
Journal ArticleDOI
Leveraging a surrogate outcome to improve inference on a partially missing target outcome
TL;DR: This work proposes Surrogate Phenotype Regression Analysis (Spray) for leveraging information from a correlated surrogate outcome to improve inference on a partially missing target outcome and describes and implements an expectation conditional maximization algorithm for performing estimation in the presence of bilateral outcome missingness.
Book ChapterDOI
Multivariate Statistical Methods in Bioinformatics Research
Lingsong Zhang,Xihong Lin +1 more
TL;DR: In this chapter, multivariate statistical methods will be reviewed, and some challenges in bioinformatic research will be also discussed.
Posted ContentDOI
A Multi-dimensional Integrative Scoring Framework for Predicting Functional Regions in the Human Genome
Xihao Li,Godwin Yung,Godwin Yung,Hufeng Zhou,Ryan Sun,Zilin Li,Yaowu Liu,Iuliana Ionita-Laza,Xihong Lin,Xihong Lin +9 more
TL;DR: The authors proposed Multi-dimensional Annotation Class Integrative Estimation (MACIE), an unsupervised multivariate mixed model framework capable of integrating annotations of diverse origin to assess multi-dimensional functional roles for both coding and non-coding variants.