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Xihong Lin
Researcher at Harvard University
Publications - 389
Citations - 32083
Xihong Lin is an academic researcher from Harvard University. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 76, co-authored 361 publications receiving 26162 citations. Previous affiliations of Xihong Lin include Texas A&M University & University of Washington.
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Journal ArticleDOI
Robust analysis of secondary phenotypes in case-control genetic association studies.
Chuanhua Xing,Janice M. McCarthy,Josée Dupuis,L. Adrienne Cupples,James B. Meigs,Xihong Lin,Andrew S. Allen +6 more
TL;DR: This paper proposes a general approach for estimating and testing the population effect of a genetic variant on a secondary phenotype based on inverse probability weighted estimating equations, where the weights depend on genotype and the secondary phenotype, and shows that it is substantially more robust to model misspecification.
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Low Bone Mineral Density in the Early Menopausal Transition: Role for Ovulatory Function
TL;DR: Lower urine estrone conjugate AUC and higher urine FSH AUC were significantly associated with lower BMD, however, luteal abnormalities based on menstrual cycle attributes were not significant associated with BMD at the total hip or lumbar spine after adjustment for age, body mass index, urinary hormone concentrations, menopausal status, and race/ethnicity.
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Prioritizing individual genetic variants after kernel machine testing using variable selection.
Qianchuan He,Tianxi Cai,Yang Liu,Ni Zhao,Quaker E. Harmon,Lynn M. Almli,Elisabeth B. Binder,Stephanie M. Engel,Kerry J. Ressler,Karen N. Conneely,Xihong Lin,Michael C. Wu +11 more
TL;DR: The approach accommodates several kernels that are widely used in SNP analysis, such as the linear kernel and the Identity by State (IBS) kernel and provides practically useful utilities to prioritize SNPs, and fills the gap between SNP set analysis and biological functional studies.
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Haplotypes of estrogen receptor-beta and risk of non-small cell lung cancer in women.
TL;DR: The findings indicate that ESR2 is not associated with risk of lung cancer in women and neither the four individual htSNPs nor their resolved haplotypes were associated with lung cancer risk in the entire population.