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Xihong Lin
Researcher at Harvard University
Publications - 389
Citations - 32083
Xihong Lin is an academic researcher from Harvard University. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 76, co-authored 361 publications receiving 26162 citations. Previous affiliations of Xihong Lin include Texas A&M University & University of Washington.
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Journal ArticleDOI
Epigenome-wide association study of total serum immunoglobulin E in children: a life course approach.
Cheng Peng,Andres Cardenas,Sheryl L. Rifas-Shiman,Marie-France Hivert,Diane R. Gold,Diane R. Gold,Thomas A.E. Platts-Mills,Xihong Lin,Emily Oken,Andrea A. Baccarelli,Augusto A. Litonjua,Dawn L. DeMeo +11 more
TL;DR: Epigenetic priming during fetal development and early childhood likely plays an important role in IgE-mediated type-I hypersensitivity, and methylation sites associated with IgE are identified using covariate-adjusted robust linear regressions.
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Multi-Omics Analysis Reveals a HIF Network and Hub Gene EPAS1 Associated with Lung Adenocarcinoma
Zhaoxi Wang,Yongyue Wei,Ruyang Zhang,Ruyang Zhang,Li Su,Stephanie M. Gogarten,Geoffrey Liu,Paul Brennan,John K. Field,James McKay,Jolanta Lissowska,Beata Swiatkowska,Vladimir Janout,Ciprian Bolca,Milica Kontic,Ghislaine Scelo,David Zaridze,Cathy C. Laurie,Kimberly F. Doheny,Elizabeth K. Pugh,Beth A. Marosy,Kurt N. Hetrick,Xiangjun Xiao,Claudio W. Pikielny,Rayjean J. Hung,Christopher I. Amos,Xihong Lin,David C. Christiani +27 more
TL;DR: An integrative analysis of multi-omic datasets of non-small cell lung cancer (NSCLC) to search for association patterns beyond the genome and transcriptome revealed a SNP in EPAS1 associated with NSCLC that reached genome-wide significance and remained significant in the entire TRICL-ILCCO consortium.
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Admixture mapping identifies novel loci for obstructive sleep apnea in Hispanic/Latino Americans.
Heming Wang,Heming Wang,Heming Wang,Brian E. Cade,Brian E. Cade,Tamar Sofer,Tamar Sofer,Scott A. Sands,Han Chen,Sharon R. Browning,Adrienne M. Stilp,Tin Louie,Timothy A. Thornton,W. Craig Johnson,Jennifer E. Below,Matthew P. Conomos,Daniel S. Evans,Sina A. Gharib,Xiuqing Guo,Alexis C. Wood,Hao Mei,Kristine Yaffe,Jose S. Loredo,Alberto R. Ramos,Elizabeth Barrett-Connor,Sonia Ancoli-Israel,Sonia Ancoli-Israel,Phyllis C. Zee,Raanan Arens,Neomi A. Shah,Kent D. Taylor,Gregory J. Tranah,Katie L. Stone,Craig L. Hanis,James G. Wilson,Daniel J. Gottlieb,Daniel J. Gottlieb,Sanjay R. Patel,Kenneth Rice,Wendy S. Post,Jerome I. Rotter,Shamil R. Sunyaev,Shamil R. Sunyaev,Jianwen Cai,Xihong Lin,Shaun Purcell,Shaun Purcell,Cathy C. Laurie,Richa Saxena,Richa Saxena,Susan Redline,Xiaofeng Zhu +51 more
TL;DR: Novel associations with variants in the iron/heme metabolism pathway suggest a role for iron in influencing respiratory traits underlying OSA in this first admixture mapping study of OSA.
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Staging reproductive aging: a comparison of proposed bleeding criteria for the menopausal transition.
TL;DR: A 60-day cycle may be a desirable marker for entry into the late transition stage because of its reliability, proximity to the FMP, and ease of calculation.
Journal ArticleDOI
Design and analysis issues in gene and environment studies
Chen-yu Liu,Arnab Maity,Arnab Maity,Xihong Lin,Robert O. Wright,Robert O. Wright,David C. Christiani +6 more
TL;DR: The purpose of this review is to discuss design and analytic issues for gene-environment interaction studies in the “-omics” era, with a focus on environmental and genetic epidemiological studies, and presents an expanded environmental genomic disease paradigm.