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Xihong Lin
Researcher at Harvard University
Publications - 389
Citations - 32083
Xihong Lin is an academic researcher from Harvard University. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 76, co-authored 361 publications receiving 26162 citations. Previous affiliations of Xihong Lin include Texas A&M University & University of Washington.
Papers
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Journal ArticleDOI
Genome-wide association and network analysis of lung function in the Framingham Heart Study.
TL;DR: A cellular network is built to explore the relationship between pulmonary function and genotypes by combining SNP level and network analyses using longitudinal lung function data from the Framingham Heart Study to identify novel genes that were not found previously using solely SNP‐level analysis.
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Estimation in semiparametric transition measurement error models for longitudinal data.
TL;DR: An estimating equation approach based on the pseudo conditional score method is proposed, and it is shown the resulting estimators of the regression coefficients are consistent and asymptotically normal.
Journal ArticleDOI
Sequencing Analysis at 8p23 Identifies Multiple Rare Variants in DLC1 Associated with Sleep-Related Oxyhemoglobin Saturation Level
Jingjing Liang,Brian E. Cade,Brian E. Cade,Brian E. Cade,Karen Y. He,Heming Wang,Heming Wang,Heming Wang,Jiwon Lee,Tamar Sofer,Tamar Sofer,Stephanie Williams,Stephanie Williams,Ruitong Li,Ruitong Li,Han Chen,Daniel J. Gottlieb,Daniel J. Gottlieb,Daniel J. Gottlieb,Daniel S. Evans,Xiuqing Guo,Sina A. Gharib,Lauren Hale,David R. Hillman,Pamela L. Lutsey,Sutapa Mukherjee,Heather M. Ochs-Balcom,Lyle J. Palmer,Jessica A Rhodes,Jessica A Rhodes,Shaun Purcell,Shaun Purcell,Shaun Purcell,Sanjay R. Patel,Richa Saxena,Katie L. Stone,Weihong Tang,Gregory J. Tranah,Eric Boerwinkle,Eric Boerwinkle,Xihong Lin,Yongmei Liu,Bruce M. Psaty,Bruce M. Psaty,Ramachandran S. Vasan,Michael H. Cho,Ani Manichaikul,Edwin K. Silverman,R. Graham Barr,Stephen S. Rich,Jerome I. Rotter,James G. Wilson,Susan Redline,Susan Redline,Susan Redline,Xiaofeng Zhu +55 more
TL;DR: Mendelian randomization analysis using six coding and 51 noncoding variants in a gene that encodes the GTPase-activating protein (DLC1) are significantly associated with AvSpO2S and replicated in independent subjects indicates a significant causal effect of DLC1 expression in fibroblasts on AvSp O2S.
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Testing for gene-environment interaction under exposure misspecification.
TL;DR: This work examines the asymptotic bias of the GxE interaction regression coefficient, allowing for confounders as well as arbitrary misspecification of the exposure and confounder effects, and shows that the regression coefficient is generally biased if the genetic factor is associated with the outcome directly or indirectly.
Journal ArticleDOI
Novel structural co-expression analysis linking the NPM1-associated ribosomal biogenesis network to chronic myelogenous leukemia
Lawrence W. C. Chan,Xihong Lin,Godwin Yung,Thomas Lui,Ya Ming Chiu,Fengfeng Wang,Nancy B.Y. Tsui,William C. Cho,Shea Ping Yip,Parco M. Siu,S. C. Cesar Wong,Benjamin Yat-Ming Yung +11 more
TL;DR: A structural strategy to identify co-expressed gene networks that are important for chronic myelogenous leukemia was developed, and a transcriptome-wide reduction of co-expression connectivity in CML was found, reflecting potentially loosened molecular regulation.