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Xihong Lin
Researcher at Harvard University
Publications - 389
Citations - 32083
Xihong Lin is an academic researcher from Harvard University. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 76, co-authored 361 publications receiving 26162 citations. Previous affiliations of Xihong Lin include Texas A&M University & University of Washington.
Papers
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Journal ArticleDOI
Functional Inference in Frailty Measurement Error Models for Clustered Survival Data Using the SIMEX Approach
Yi Li,Xihong Lin +1 more
TL;DR: In this paper, the authors consider the effect of measurement errors in covariates on the performance of the SIMEX method and compare it with the likelihood method in terms of efficiency and robustness.
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Plasma Neutrophil Elastase and Elafin Imbalance Is Associated with Acute Respiratory Distress Syndrome (ARDS) Development
Zhaoxi Wang,Feng Chen,Rihong Zhai,Lingsong Zhang,Li Su,Xihong Lin,Taylor Thompson,David C. Christiani +7 more
TL;DR: Testing the hypothesis that an imbalance between neutrophil elastase (HNE) and its inhibitors in blood is related to the development of ARDS found that plasma profiles of PI3, HNE, and HNE/PI3 may be useful clinical biomarkers in monitoring the development.
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Cigarette smoking increases copy number alterations in nonsmall-cell lung cancer
Yen-Tsung Huang,Xihong Lin,Yan Liu,Lucian R. Chirieac,Ray McGovern,John C. Wain,Rebecca S. Heist,Vidar Skaug,Shanbeh Zienolddiny,Aage Haugen,Li Su,Edward A. Fox,Kwok-Kin Wong,David C. Christiani +13 more
TL;DR: It is found that heavy cigarette smokers have significantly more copy number gains than non- or light smokers (≤60 pack-years) and leads to morecopy number alterations, which may be mediated by the genome instability.
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Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease
Brian D. Hobbs,Margaret M. Parker,Han Chen,Taotao Lao,Megan Hardin,Dandi Qiao,Iwona Hawryłkiewicz,Pawel Sliwinski,Jae-Joon Yim,Woo Jin Kim,Deog Kyeom Kim,Peter J. Castaldi,Craig P. Hersh,Jarrett D. Morrow,Bartolome R. Celli,Victor Pinto-Plata,G.J. Criner,Nathaniel Marchetti,Raphael Bueno,Alvar Agusti,Barry J. Make,James D. Crapo,Peter M.A. Calverley,Claudio F. Donner,David A. Lomas,Emiel F.M. Wouters,J Vestbo,Peter D. Pare,Robert D. Levy,Stephen I. Rennard,Xiaobo Zhou,Nan M. Laird,Xihong Lin,Terri H. Beaty,Edwin K. Silverman,Michael H. Cho +35 more
TL;DR: In an exome array analysis of COPD, nonsynonymous variants at previously described loci and a novel exome-wide significant variant in IL27 are identified and appears to affect genes potentially related to COPD pathogenesis.
Journal ArticleDOI
Linear mixed models with heterogeneous within-cluster variances
TL;DR: Unbiased estimating equations based on quasilikelihood/pseudolikelihood and method of moments are introduced and are shown to give consistent estimators of the regression coefficients, variance components, and heterogeneity parameter under regularity conditions.