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Xihong Lin
Researcher at Harvard University
Publications - 389
Citations - 32083
Xihong Lin is an academic researcher from Harvard University. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 76, co-authored 361 publications receiving 26162 citations. Previous affiliations of Xihong Lin include Texas A&M University & University of Washington.
Papers
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Journal ArticleDOI
Estimating causal effects in trials involving multitreatment arms subject to non-compliance: A Bayesian framework
TL;DR: A likelihood-based framework that models potential outcomes in this setting and a Bayes procedure for statistical inference is proposed and is compared with a method of moments approach proposed by Cheng & Small (2006).
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CpGFilter: model-based CpG probe filtering with replicates for epigenome-wide association studies
Jun Chen,Jun Chen,Allan C. Just,Joel Schwartz,Lifang Hou,Nadereh Jafari,Zhifu Sun,Jean-Pierre A. Kocher,Andrea A. Baccarelli,Xihong Lin +9 more
TL;DR: This work proposes to use intra-class correlation coefficient (ICC), which characterizes the relative contribution of the biological variability to the total variability, to filter CpGs when technical replicates are available to estimate the ICC based on a linear mixed effects model by pooling all the samples.
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Genome-wide gene-asbestos exposure interaction association study identifies a common susceptibility variant on 22q13.31 associated with lung cancer risk
Chen-yu Liu,Isabelle Stücker,Chu Chen,Gary E. Goodman,Michelle K. McHugh,Anthony M. D'Amelio,Carol J. Etzel,Su Li,Xihong Lin,David C. Christiani +9 more
TL;DR: This study is the first report using a systematic genome-wide analysis in combination with detailed asbestos exposure data and replication to evaluate asbestos-associated lung cancer risk and suggests that MIRLET7BHG polymorphisms may be important predictive markers for asbestos exposure–related lung cancer.
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Epigenome-wide association analysis of daytime sleepiness in the Multi-Ethnic Study of Atherosclerosis reveals African-American-specific associations.
Richard Barfield,Richard Barfield,Heming Wang,Heming Wang,Heming Wang,Yongmei Liu,Jennifer A. Brody,Brenton R. Swenson,Ruitong Li,Ruitong Li,Traci M. Bartz,Nona Sotoodehnia,Yii-Der Ida Chen,Brian E. Cade,Brian E. Cade,Brian E. Cade,Han Chen,Han Chen,Sanjay R. Patel,Xiaofeng Zhu,Sina A. Gharib,W. Craig Johnson,Jerome I. Rotter,Richa Saxena,Shaun Purcell,Shaun Purcell,Xihong Lin,Susan Redline,Susan Redline,Susan Redline,Tamar Sofer,Tamar Sofer +31 more
TL;DR: The association between DNAm and daytime sleepiness quantified by the Epworth Sleepiness Scale was explored and methylation sites in multiple genes possibly implicated in daytimeSleepiness were identified.
Journal ArticleDOI
Variants in angiopoietin-2 (ANGPT2) contribute to variation in nocturnal oxyhaemoglobin saturation level.
Heming Wang,Bärian E. Cade,Han Chen,Kevin J. Gleason,Kevin J. Gleason,Richa Saxena,Richa Saxena,Tao Feng,Emma K. Larkin,Ramachandran S. Vasan,Ramachandran S. Vasan,Honghuang Lin,Sanjay R. Patel,Russell P. Tracy,Yongmei Liu,Daniel J. Gottlieb,Daniel J. Gottlieb,Jennifer E. Below,Craig L. Hanis,Lauren E. Petty,Shamil R. Sunyaev,Shamil R. Sunyaev,Alexis C. Frazier-Wood,Jerome I. Rotter,Wendy S. Post,Xihong Lin,Susan Redline,Xiaofeng Zhu +27 more
TL;DR: This study provides the first evidence for the association of ANGPT2, a gene previously implicated in acute lung injury syndromes, with nocturnal SaO2, suggesting that this gene has a broad range of effects on gas exchange, including influencing oxygenation during sleep.