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Xihong Lin
Researcher at Harvard University
Publications - 389
Citations - 32083
Xihong Lin is an academic researcher from Harvard University. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 76, co-authored 361 publications receiving 26162 citations. Previous affiliations of Xihong Lin include Texas A&M University & University of Washington.
Papers
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Journal ArticleDOI
Simultaneous Detection of Signal Regions Using Quadratic Scan Statistics With Applications in Whole Genome Association Studies
Zilin Li,Yaowu Liu,Xihong Lin +2 more
TL;DR: In this article, the authors proposed a computationally efficient quadratic scan (Q-SCAN) statistic based method to detect the existence and the locations of signal regions by scanning the genome continuously.
Posted ContentDOI
Epigenome-wide association analysis of daytime sleepiness in the Multi-Ethnic Study of Atherosclerosis reveals African-American specific associations
Richard Barfield,Heming Wang,Yongmei Liu,Jennifer A. Brody,Brenton R. Swenson,Ruitong Li,Traci M. Bartz,Nona Sotoodehnia,Yii-Der Ida Chen,Brian E. Cade,Han Chen,Sanjay R. Patel,Xiaofeng Zhu,Sina A. Gharib,W. Craig Johnson,Jerome I. Rotter,Richa Saxena,Shaun Purcell,Xihong Lin,Susan Redline,Tamar Sofer +20 more
TL;DR: The authors' analysis identified methylation sites in multiple genes that may be implicated in EDS, specific to African Americans, and identified a sleepiness-associated methylation site in the gene RAI1, a gene associated with sleep and circadian phenotypes.
Journal ArticleDOI
Association of progression-free survival with overall survival (OS) in patients (pts) with neuroendocrine tumor (NET) treated with somatostatin analogs.
Monica Ter-Minassian,Nichole V. Brooks,Lauren K. Brais,Jennifer A. Chan,David C. Christiani,Xihong Lin,Sylvie Gabriel,Jerome Dinet,Matthew H. Kulke +8 more
TL;DR: A large observational cohort of pts with NETs treated with somatostatin analogs who had received single-agent SSA and were evaluable for tumor progression assessed the association between PFS and OS in a large observational study.
Posted ContentDOI
The common neoantigens in colorectal cancer are predicted and validated to be presented or immunogenic
Liang Z,Qin L,Lingli Chen,Wei Li,C. T. Chen,Yunchao Huang,L. Zhang,Suyan Liu,Si Qiu,Ying Ge,Wanling Peng,Xihong Lin,Dong X,Xiaotian Zhang,Baisheng Li +14 more
TL;DR: Common neoantigens with presentation and immunogenicity could be found in CRC, which would be developed as the universal targets for CRC immunotherapy.
Journal ArticleDOI
A Variance-Component Framework for Pedigree Analysis of Continuous and Categorical Outcomes.
Michael P. Epstein,Jessica Ezzell Hunter,Emily G. Allen,Stephanie L. Sherman,Xihong Lin,Michael Boehnke +5 more
TL;DR: This paper develops and applies a general variance- component framework for pedigree analysis of continuous and categorical outcomes and demonstrates that one can perform variance-component pedigree analysis on outcomes that follow any exponential-family distribution.