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Xuejun Qin
Researcher at Duke University
Publications - 44
Citations - 1321
Xuejun Qin is an academic researcher from Duke University. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 17, co-authored 40 publications receiving 1055 citations. Previous affiliations of Xuejun Qin include Veterans Health Administration & Durham University.
Papers
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Journal ArticleDOI
Apolipoprotein E controls the risk and age at onset of Parkinson disease
Yi-Ju Li,Michael A. Hauser,William K. Scott,Eden R. Martin,Michael W. Booze,Xuejun Qin,Jeffrey W. Walter,M. Nance,Jean P. Hubble,William C. Koller,Rajesh Pahwa,M.B. Stern,Bradley C. Hiner,Joseph Jankovic,Christopher G. Goetz,Gary W. Small,Francis Mastaglia,Jonathan L. Haines,Margaret A. Pericak-Vance,Jeffery M. Vance +19 more
TL;DR: The APOE-4 allele increases risk and decreases age at onset of PD, an association that may not be dependent upon cognitive impairment, and was significantly associated with risk of developing PD.
Journal Article
Analysis of LOXL1 polymorphisms in a United States population with pseudoexfoliation glaucoma.
Pratap Challa,Silke Schmidt,Yutao Liu,Xuejun Qin,Robin Vann,Pedro Gonzalez,R. Rand Allingham,Michael A. Hauser +7 more
TL;DR: An analysis of LOXL1 and XFG in a United States patient population and has confirmed the strong association previously reported for Icelandic and Swedish samples, however, due to the high frequency of risk alleles in non-XFG individuals, this association should not form the basis of a diagnostic test for XFG.
Journal ArticleDOI
Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy.
Natalie A. Afshari,Robert P. Igo,Nathan Morris,Dwight Stambolian,Shiwani Sharma,V. Lakshmi Pulagam,Steven P. Dunn,John F. Stamler,Barbara Truitt,J. B. Rimmler,Abraham Kuot,Christopher R. Croasdale,Xuejun Qin,Kathryn P. Burdon,Kathryn P. Burdon,S. Amer Riazuddin,Richard A. Mills,Sonja Klebe,Mollie A. Minear,Jiagang Zhao,Elmer Balajonda,George O D Rosenwasser,Keith H. Baratz,Venkateswara Mootha,Sanjay V. Patel,Simon G. Gregory,Joan E. Bailey-Wilson,Marianne O. Price,Francis W. Price,Jamie E Craig,John H. Fingert,John D. Gottsch,Anthony J. Aldave,Gordon K. Klintworth,Jonathan H. Lass,Yi-Ju Li,Sudha K. Iyengar +36 more
TL;DR: The knowledge of common FECD loci is expanded from one to four, and a deeper understanding of the underlying pathogenic basis of FECD is provided, to understand the genetic aetiology of Fuchs endothelial corneal dystrophy.
Journal Article
Major LOXL1 risk allele is reversed in exfoliation glaucoma in a black South African population.
Susan Williams,Benjamin T. Whigham,Yutao Liu,Trevor R. Carmichael,Xuejun Qin,Silke Schmidt,Michèle Ramsay,Michael A. Hauser,R. Rand Allingham +8 more
TL;DR: Surprisingly, the G allele of the major susceptibility variant rs3825942 has consistently been shown in multiple populations to increase the risk of XFG and is found with a strong association with the opposite allele in the South African population.
Journal ArticleDOI
Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis.
William E. Kraus,Deborah M. Muoio,Robert Stevens,Damian M. Craig,James R. Bain,Elizabeth Grass,Carol Haynes,Lydia Coulter Kwee,Xuejun Qin,Dorothy H. Slentz,Deidre R. Krupp,Michael J. Muehlbauer,Elizabeth R. Hauser,Simon G. Gregory,Christopher B. Newgard,Svati H. Shah +15 more
TL;DR: The integrative strategy implicates the UPS arm of the ER stress pathway in CVD pathogenesis, and identifies novel genetic loci associated with CVD event risk.