Y
Yakov Chudnovsky
Researcher at Massachusetts Institute of Technology
Publications - 3
Citations - 473
Yakov Chudnovsky is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: PKM2 & Glycine cleavage system. The author has an hindex of 3, co-authored 3 publications receiving 389 citations. Previous affiliations of Yakov Chudnovsky include Broad Institute.
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SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance
Dohoon Kim,Brian P. Fiske,Kıvanç Birsoy,Elizaveta Freinkman,Kenjiro Kami,Richard Possemato,Yakov Chudnovsky,Michael E. Pacold,Walter W. Chen,Jason R. Cantor,Laura M. Shelton,Dan Y. Gui,Manjae Kwon,Shakti Ramkissoon,Keith L. Ligon,Seong Woo Anthony Kang,Matija Snuderl,Matthew G. Vander Heiden,David M. Sabatini +18 more
TL;DR: A key role is identified for serine and glycine metabolism in the survival of brain cancer cells within the ischaemic zones of gliomas and SHMT2 activity limits that of pyruvate kinase and reduces oxygen consumption, eliciting a metabolic state that confers a profound survival advantage to cells in poorly vascularized tumour regions.
Journal ArticleDOI
ZFHX4 Interacts with the NuRD Core Member CHD4 and Regulates the Glioblastoma Tumor-Initiating Cell State
Yakov Chudnovsky,Yakov Chudnovsky,Dohoon Kim,Siyuan Zheng,Warren A. Whyte,Mukesh Bansal,Mark-Anthony Bray,Shuba Gopal,Matthew A. Theisen,Steve Bilodeau,Prathapan Thiru,Julien Muffat,Ömer H. Yilmaz,Maya Mitalipova,Kevin D. Woolard,Jeongwu Lee,Riko Nishimura,Nobuo Sakata,Howard A. Fine,Anne E. Carpenter,Serena J. Silver,Roel G.W. Verhaak,Andrea Califano,Richard A. Young,Keith L. Ligon,Ingo K. Mellinghoff,Ingo K. Mellinghoff,David E. Root,David M. Sabatini,William C. Hahn,William C. Hahn,Milan G. Chheda,Milan G. Chheda,Milan G. Chheda +33 more
TL;DR: ZFHX4 is defined as a regulatory factor that links the chromatin-remodeling NuRD complex and the GBM TIC state and as a master regulator of CHD4, a core member of the nucleosome remodeling and deacetylase (NuRD) complex.
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance
Dohoon Kim,Brian P. Fiske,Kıvanç Birsoy,Elizaveta Freinkman,Kenjiro Kami,Richard Possemato,Yakov Chudnovsky,Michael E. Pacold,Walter W. Chen,Jason R. Cantor,Laura M. Shelton,Dan Y. Gui,Manjae Kwon,Shakti Ramkissoon,Keith L. Ligon,Seong Woo Anthony Kang,Matija Snuderl,Matthew G. Vander Heiden,David M. Sabatini +18 more
TL;DR: In this article, the authors identify a key role for serine and glycine metabolism in the survival of brain cancer cells within the ischaemic zones of gliomas, and show that SHMT2 activity limits that of pyruvate kinase (PKM2) and reduces oxygen consumption, eliciting a metabolic state that confers a profound survival advantage to cells in poorly vascularized tumour regions.