C
Christian Jäger
Researcher at University of Luxembourg
Publications - 28
Citations - 2427
Christian Jäger is an academic researcher from University of Luxembourg. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 15, co-authored 23 publications receiving 1712 citations. Previous affiliations of Christian Jäger include Braunschweig University of Technology.
Papers
More filters
Journal ArticleDOI
Generation of genome-scale metabolic reconstructions for 773 members of the human gut microbiota
Stefania Magnusdottir,Almut Heinken,Laura Kutt,Dmitry A. Ravcheev,Eugen Bauer,Alberto Noronha,Kacy Greenhalgh,Christian Jäger,Joanna Baginska,Paul Wilmes,Ronan M. T. Fleming,Ines Thiele +11 more
TL;DR: This work presents AGORA (assembly of gut organisms through reconstruction and analysis), a resource of genome-scale metabolic reconstructions semi-automatically generated for 773 human gut bacteria, and identified a defined growth medium for Bacteroides caccae ATCC 34185.
Journal ArticleDOI
A microfluidics-based in vitro model of the gastrointestinal human-microbe interface.
Pranjul Shah,Joëlle V. Fritz,Enrico Glaab,Mahesh Desai,Kacy Greenhalgh,Audrey Frachet,Magdalena Niegowska,Matthew Estes,Christian Jäger,Carole Seguin-Devaux,Frederic Zenhausern,Paul Wilmes +11 more
TL;DR: The ability of HuMiX to recapitulate in vivo transcriptional, metabolic and immunological responses in human intestinal epithelial cells following their co-culture with the commensal Lactobacillus rhamnosus GG (LGG) grown under anaerobic conditions is demonstrated.
Journal ArticleDOI
MetaboliteDetector: comprehensive analysis tool for targeted and nontargeted GC/MS based metabolome analysis
Karsten Hiller,Jasper Hangebrauk,Christian Jäger,Jana Spura,Kerstin Schreiber,Dietmar Schomburg +5 more
TL;DR: The intuitive graphical user interface of MetaboliteDetector additionally allows for a detailed examination of a single GC/MS chromatogram including single ion chromatograms, recorded mass spectra, and identified metabolite spectra in combination with the corresponding reference spectra obtained from a reference library.
Journal ArticleDOI
Glutathione Primes T Cell Metabolism for Inflammation
Tak W. Mak,Tak W. Mak,Melanie Grusdat,Gordon S. Duncan,Catherine Dostert,Yannic Nonnenmacher,Yannic Nonnenmacher,Maureen A. Cox,Carole Binsfeld,Zhenyue Hao,Zhenyue Hao,Anne Brüstle,Momoe Itsumi,Christian Jäger,Ying Chen,Olaf Pinkenburg,Bärbel Camara,Markus Ollert,Carsten Bindslev-Jensen,Vasilis Vasiliou,Chiara Gorrini,Philipp A. Lang,Michael Lohoff,Isaac S. Harris,Karsten Hiller,Karsten Hiller,Dirk Brenner +26 more
TL;DR: It is reported that GSH is essential for T cell effector functions through its regulation of metabolic activity and plays an unexpected role in metabolic integration and reprogramming during inflammatory T cell responses.
Journal ArticleDOI
The metabolic response of P. putida KT2442 producing high levels of polyhydroxyalkanoate under single- and multiple-nutrient-limited growth: Highlights from a multi-level omics approach
Ignacio Poblete-Castro,Isabel F. Escapa,Christian Jäger,Jacek Puchałka,Carolyn M.C. Lam,Dietmar Schomburg,María Auxiliadora Prieto,Vitor A. P. Martins dos Santos +7 more
TL;DR: This is the first study where the interrelationship between nutrient limitations and PHA synthesis has been investigated under well-controlled conditions using a system level approach and will be of great assistance for the development of bioprocesses and further metabolic engineering work in this versatile organism.