Yariv Wine

TL;DR: The fidelity of VH:VL pairs identified by this approach were validated and the method was used to sequence the repertoire of three human cell subsets—peripheral blood IgG+ B cells, peripheral plasmablasts isolated after tetanus toxoid immunization and memory B cells isolated after seasonal influenza vaccination.

TL;DR: The results suggest that only a small fraction of responding peripheral B cells give rise to the bone marrow long-lived plasma cells responsible for the production of biologically relevant amounts of vaccine-specific antibodies in the serological memory response 9 mo postvaccination.

TL;DR: Feasibility study and results obtained from a new approach to investigate the process of protein crystals stabilization by glutaraldehyde crosslinking showed that reaction rate was much faster at alkaline pH, and different reaction end products, indicating different reaction mechanisms, were identified for crossl linking taking place under alkaline or acidic conditions.

TL;DR: The ability to deconvolute the polyclonal serum response is likely to be of key importance for analyzing antibody responses after vaccination and for more completely understanding adaptive immune responses in health and disease.

TL;DR: The purpose of this perspective is to provide an overview of the AIRR Community’s founding principles and present the progress that the community has made in developing standards of practice and data sharing protocols.